{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:39:16Z","timestamp":1747190356405,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2020,6,17]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Lymphoma of the appendix is a rare cause of acute appendicitis; however, acute appendicitis is a common first manifestation of appendiceal lymphomas. Cytotoxic peripheral T cell lymphoma (PTCL) is a type of aggressive non-Hodgkin lymphoma that portends a generally poor outcome. Cytotoxic PTCL of the appendix is extremely rare with few cases reported in the literature. <jats:italic>Case Presentation<\/jats:italic>. This is the report of a 23-year-old man who had experienced lower abdominal pain for three months before presenting to the emergency department with severe right lower abdominal pain, nausea, vomiting, and anorexia since the day prior to admission. The patient was diagnosed with acute appendicitis, and the pathology report confirmed cytotoxic PTCL of the appendix. <jats:italic>Conclusion<\/jats:italic>. Patients with appendiceal PTCL commonly present with signs and symptoms of acute appendicitis due to luminal obstruction by the tumor. Therefore, appendiceal tumors such as PTCL should be considered in the differential diagnosis of patients presenting as acute appendicitis. In addition, since there is no standard chemotherapy regimen for cytotoxic PTCL, this and other case reports hopefully help in providing the clinical evidence needed for establishing appropriate treatment guidelines.<\/jats:p>","DOI":"10.1155\/2020\/8569426","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T23:31:08Z","timestamp":1592436668000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral Cytotoxic T Cell Lymphoma of the Appendix Presenting as Acute Appendicitis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-3723","authenticated-orcid":true,"given":"Negin","family":"Rahmani","sequence":"first","affiliation":[{"name":"Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8906-5473","authenticated-orcid":true,"given":"Yahya","family":"Daneshbod","sequence":"additional","affiliation":[{"name":"Shiraz Molecular Pathology Research Center, Dr. Daneshbod Lab, Shiraz, Iran"},{"name":"Department of Pathology and Laboratory Medicine, Loma Linda University, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9299-8928","authenticated-orcid":true,"given":"Hadi","family":"Mirfazaelian","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5587-4085","authenticated-orcid":true,"given":"Elnaz","family":"Vahidi","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4137-9056","authenticated-orcid":true,"given":"Sadegh","family":"Shirian","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran"},{"name":"Biotechnology Research Institute, Shahrekord University, Shahrekord, Iran"},{"name":"Shefa Neuroscience Research Center, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9329"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2004.11.006"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/728579"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1148\/rg.233025134"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv201"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i6.697"},{"issue":"6","key":"7","first-page":"1121","volume":"33","year":"2008","journal-title":"International Journal of Oncology"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2000.01037.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0524"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2243011545"},{"issue":"2","key":"11","first-page":"160","volume":"9","year":"2014","journal-title":"Iranian Journal of Pathology"},{"issue":"10","key":"12","first-page":"7068","volume":"7","year":"2014","journal-title":"International journal of clinical and experimental pathology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-8-2"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-5"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2020\/8569426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2020\/8569426.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crionm\/2020\/8569426.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T23:31:14Z","timestamp":1592436674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crionm\/2020\/8569426\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":14,"alternative-id":["8569426","8569426"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8569426","relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"type":"print","value":"2090-6706"},{"type":"electronic","value":"2090-6714"}],"subject":[],"published":{"date-parts":[[2020,6,17]]}}}