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This meta\u2010analysis was conducted to evaluate the influence of Kanglaite injection (KLTi) combined with chemotherapy versus chemotherapy alone on clinical efficacy, immune function, and safety for the treatment of advanced non\u2010small\u2010cell lung cancer (NSCLC). Several electronic databases, including PubMed, Web of Science, Wan\u2010Fang, VMIS, EMBASE, Cochrane Library, CNKI, CBM, and MEDLINE, as well as grey literatures, were comprehensively searched from January 2000 to November 2019. Randomized controlled trials (RCTs) reporting outcomes of clinical efficacy and immune function were collected according to their inclusion and exclusion criteria. Cochrane Reviewers\u2019 Handbook 5.2 was applied to assess the risk of bias of included trials. STATA 13.0 and Review Manager 5.3 software were used for meta\u2010analysis. Twenty\u2010five RCTs comprising 2151 patients meeting the inclusion criteria were identified. Meta\u2010analysis showed that compared with chemotherapy alone, KLTi plus the same chemotherapy significantly improved clinical efficacy, including complete response, partial response, stable disease, and progressive disease, as well as immune function, including CD<jats:sup>3+<\/jats:sup>, CD<jats:sup>4+<\/jats:sup>, CD<jats:sup>8+<\/jats:sup>, and CD<jats:sup>4+<\/jats:sup>\/CD<jats:sup>8+<\/jats:sup>. There was a significant reduction in nausea and vomiting, thrombocytopenia, and leukopenia in combination treatments. However, the outcomes were limited because of the low quality and small sample size of the included studies. In conclusion, this work might provide beneficial evidence of KLTi combined with chemotherapy for improving clinical efficacy and immune function, as well as reducing the incidence of adverse events in advanced NSCLC patients. KLTi might be a beneficial therapeutic method for the treatment of advanced NSCLC. Due to the quality of the data, more rigorous and well\u2010designed RCTs are needed to confirm these findings.<\/jats:p>","DOI":"10.1155\/2020\/8586596","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T23:31:35Z","timestamp":1580167895000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Kanglaite Injection Combined with Chemotherapy versus Chemotherapy Alone for the Improvement of Clinical Efficacy and Immune Function in Patients with Advanced Non\u2010Small\u2010Cell Lung Cancer: A Systematic Review and 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