{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T03:12:40Z","timestamp":1783912360094,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stroke Research and Treatment"],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group. <jats:italic>Methods<\/jats:italic>. Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF. <jats:italic>Results<\/jats:italic>. The mean age of the RHRF (-) group (43.2\u2009\u00b1\u200913 years) was significantly higher than of the RHRF (+) group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>34<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:math> years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn>38<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:math> years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%). <jats:italic>Conclusion<\/jats:italic>. The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.<\/jats:p>","DOI":"10.1155\/2020\/8610903","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T23:33:03Z","timestamp":1599003183000},"page":"1-8","source":"Crossref","is-referenced-by-count":11,"title":["Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3811-5017","authenticated-orcid":true,"given":"Derya","family":"Uluduz","sequence":"first","affiliation":[{"name":"School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-9965","authenticated-orcid":true,"given":"Sevki","family":"Sahin","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Neurology, Maltepe University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-4193","authenticated-orcid":true,"given":"Taskin","family":"Duman","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Neurology, Mustafa Kemal University, Hatay, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8986-155X","authenticated-orcid":true,"given":"Serefnur","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Selcuk University, School of Medicine, Department of Neurology, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4188-0898","authenticated-orcid":true,"given":"Vildan","family":"Yayla","sequence":"additional","affiliation":[{"name":"University of Health Science, Hamidiye School of Medicine, Sadi Konuk Research and Training Hospital, Department of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8123-8560","authenticated-orcid":true,"given":"Nazire","family":"Afsar","sequence":"additional","affiliation":[{"name":"Acibadem University, School of Medicine, Department of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4961-4332","authenticated-orcid":true,"given":"Nevzat","family":"Uzuner","sequence":"additional","affiliation":[{"name":"Osmangazi University, School of Medicine, Department of Neurology, Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5125-3708","authenticated-orcid":true,"given":"Ipek","family":"Midi","sequence":"additional","affiliation":[{"name":"Marmara University, School of Medicine, Department of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-3137","authenticated-orcid":true,"given":"Nilgun","family":"Cinar","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Neurology, Maltepe University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5380-0819","authenticated-orcid":true,"given":"Mehmet Ali","family":"Sungur","sequence":"additional","affiliation":[{"name":"Duzce University, School of Medicine, Department of Biostatistics, Duzce, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3576-0344","authenticated-orcid":true,"given":"Fusun Mayda","family":"Domac","sequence":"additional","affiliation":[{"name":"University of Health Science, Hamidiye School of Medicine, Erenkoy Research and Training Hospital for Neurologic and Psychiatric Diseases, Department of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birsen","family":"Ince","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baki","family":"Goksan","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemile Handan","family":"Misirli","sequence":"additional","affiliation":[{"name":"University of Health Science, Hamidiye School of Medicine, Haydarpasa Training and Research Hospital, Department of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Bakar","sequence":"additional","affiliation":[{"name":"Uludag University, School of Medicine, Department of Neurology, Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Huseyin","family":"Kozak","sequence":"additional","affiliation":[{"name":"Nemettin Erbakan University, School of Medicine, Department of Neurology, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena","family":"Colakoglu","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Neurology, Mustafa Kemal University, Hatay, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8142-913X","authenticated-orcid":true,"given":"Ali Yavuz","family":"Karahan","sequence":"additional","affiliation":[{"name":"Usak University, School of Medicine, Department of Physical Medicine and Rehabilitation, Usak, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eylem Ozaydin","family":"Goksu","sequence":"additional","affiliation":[{"name":"Antalya Research and Training Hospital, Clinic of Neurology, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Ozdag","sequence":"additional","affiliation":[{"name":"University of Health Science, Hamidiye School of Medicine, Sultan Abdulhamid Han Research and Training Hospital, Department of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Guney","family":"Senol","sequence":"additional","affiliation":[{"name":"University of Health Science, Hamidiye School of Medicine, Sultan Abdulhamid Han Research and Training Hospital, Department of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat Ali","family":"Yurekli","sequence":"additional","affiliation":[{"name":"Suleyman Demirel University, School of Medicine, Department of Neurology, Isparta, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ufuk","family":"Aluclu","sequence":"additional","affiliation":[{"name":"Dicle University, School of Medicine, Department of Neurology, Diyarbak\u0131r, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkan","family":"Demir","sequence":"additional","affiliation":[{"name":"Sancaktepe Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayriye","family":"Kucukoglu","sequence":"additional","affiliation":[{"name":"Sultan Abdulhamid Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Oruc","sequence":"additional","affiliation":[{"name":"Kocatepe University, School of Medicine, Department of Neurology, Afyon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilufer","family":"Yesilot","sequence":"additional","affiliation":[{"name":"Istanbul University, School of Medicine, Department of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge Yimaz","family":"Kusbeci","sequence":"additional","affiliation":[{"name":"Bozyaka Education, Research and Traning Hospital, Clinic of Neurology, Izmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6148-3814","authenticated-orcid":true,"given":"Bijen","family":"Nazliel","sequence":"additional","affiliation":[{"name":"Gazi University, School of Medicine, Department of Neurology, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdevs Ezgi Ucan","family":"Tokuc","sequence":"additional","affiliation":[{"name":"Antalya Research and Training Hospital, Clinic of Neurology, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesna","family":"Bektas","sequence":"additional","affiliation":[{"name":"Ataturk Research and Training Hospital, Clinic of Neurology, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Nida","family":"Tascilar","sequence":"additional","affiliation":[{"name":"Bulent Ecevit University, School of Medicine, Department of Neurology, Zonguldak, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"Aytac","sequence":"additional","affiliation":[{"name":"Firat University, School of Medicine, Department of Neurology, Elazig, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Gokce","sequence":"additional","affiliation":[{"name":"Sutcu Imam University, School of Medicine, Department of Neurology, Kahramanmaras, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hale Zeynep Batur","family":"Caglayan","sequence":"additional","affiliation":[{"name":"Gazi University, School of Medicine, Department of Neurology, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Tufekci","sequence":"additional","affiliation":[{"name":"Recep Tayyip Erdogan University, School of Medicine, Department of Neurology, Rize, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulnur","family":"Uzuner","sequence":"additional","affiliation":[{"name":"Osmangazi University, School of Medicine, Department of Neurology, Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek Necioglu","family":"Orken","sequence":"additional","affiliation":[{"name":"Bilim University, School of Medicine, Department of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman Ozgur","family":"Yalin","sequence":"additional","affiliation":[{"name":"Istanbul Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uygar","family":"Utku","sequence":"additional","affiliation":[{"name":"Sutcu Imam University, School of Medicine, Department of Neurology, Kahramanmaras, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arda","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Mersin University, School of Medicine, Department of Neurology, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamit","family":"Genc","sequence":"additional","affiliation":[{"name":"Mersin University, School of Medicine, Department of Neurology, Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Cabalar","sequence":"additional","affiliation":[{"name":"Sadi Konuk Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysel","family":"Milanlioglu","sequence":"additional","affiliation":[{"name":"Yuzuncu Yil University, School of Medicine, Department of Neurology, Van, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Ekmekci","sequence":"additional","affiliation":[{"name":"Selcuk University, School of Medicine, Department of Neurology, Konya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Zeydan","sequence":"additional","affiliation":[{"name":"Mayo Clinic, College of Medicine, Department of Neurology, Rochester, MN., USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevim","family":"Baybas","sequence":"additional","affiliation":[{"name":"Bakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurology Training and Research Hospital, Clinic of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuksel","family":"Kablan","sequence":"additional","affiliation":[{"name":"Inonu University, School of Medicine, Department of Neurology, Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basak Karakurum","family":"Goksel","sequence":"additional","affiliation":[{"name":"Baskent University, School of Medicine, Department of Neurology, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Acikgoz","sequence":"additional","affiliation":[{"name":"Bulent Ecevit University, School of Medicine, Department of Neurology, Zonguldak, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"Kurucu","sequence":"additional","affiliation":[{"name":"School of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seden","family":"Demirci","sequence":"additional","affiliation":[{"name":"Akdeniz University, School of Medicine, Department of Neurology, Antalya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taskin","family":"Gunes","sequence":"additional","affiliation":[{"name":"Maltepe Government Hospital, Clinic of Neurology, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.04.020"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30235-4"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3171\/2009.8.focus09158"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.543884"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.12.1880"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra042354"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000117571.76197.26"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000177894.05495.54"},{"issue":"8","key":"9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrcardio.2015.83","volume":"12","year":"2015","journal-title":"Nature Reviews Cardiology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31820ce2db"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02921.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.12.2948"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.6.1274"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2217\/17455057.3.4.487"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000000230"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-10-200511150-00006"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2017.02.046"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.8.1793"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5703.203"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2011.06.011"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182041"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.6.814"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01804.x"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-012237"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198603000-00002"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-014-0532-1"}],"container-title":["Stroke Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/srt\/2020\/8610903.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/srt\/2020\/8610903.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/srt\/2020\/8610903.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T23:33:06Z","timestamp":1599003186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/srt\/2020\/8610903\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":26,"alternative-id":["8610903","8610903"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8610903","relation":{},"ISSN":["2090-8105","2042-0056"],"issn-type":[{"value":"2090-8105","type":"print"},{"value":"2042-0056","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}