{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:08:18Z","timestamp":1782781698665,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":215,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Interstitial pregnancy (IP) is an ectopic pregnancy (EP) located in the portion of the fallopian tube that penetrates the uterine muscular layer. Incidence increased in the last two decades with the widespread use of the assisted reproductive techniques. It is estimated in 1\u20106% of all the EPs, with a maternal mortality rate of 2.0\u20102.5%. Clinical presentation, gestational age at diagnosis, beta\u2010human chorionic gonadotropin (<jats:italic>\u03b2<\/jats:italic>\u2010hCG) levels, ultrasound features, and patient preference, should be considered to determine the best management: surgical, medical treatment, or close observation. We report two cases of IP successfully managed with systemic MTX and Mifepristone: in one case <jats:italic>\u03b2<\/jats:italic>\u2010hCG was &gt;10.000\u2009mIU\/mL and a vital embryo was present. <jats:italic>Materials and Methods<\/jats:italic>. A literature search was carried out on MEDLINE, EMBASE, and PUBMED. We identified two cases of IP referred to the Institute for Maternal and Child Burlo Garofolo, Trieste. Data related to clinical presentation, <jats:italic>\u03b2<\/jats:italic>\u2010hCG, and ultrasound scan at the moment of the diagnosis were recorded. In one of the cases, the <jats:italic>\u03b2<\/jats:italic>\u2010hCG level was &gt;10.000\u2009mIU\/mL, and a vital embryo was testified at an ultrasound scan. The patient was asymptomatic and she was treated using multidose systemic Methotrexate (MTX) combined with Mifepristone. In the second case, in the presence of a clinically stable patient with <jats:italic>\u03b2<\/jats:italic> \u2212 hCG &gt; 10.000\u2009mIU\/mL, it was chosen that the administration of Mifepristone combined with a double dose of MTX. <jats:italic>\u03b2<\/jats:italic>\u2010hCG levels and ultrasound examinations were performed weekly until a complete resolution of the IP. <jats:italic>Results<\/jats:italic>. In the first case, <jats:italic>\u03b2<\/jats:italic>\u2010hCG dropped down in 5 days and became undetachable in 30 days. In the second case, <jats:italic>\u03b2<\/jats:italic>\u2010hCG became undetectable in 47 days. The first\u2010line therapy in asymptomatic women could be addressed to a combined protocol, consisting of a systemic multidose MTX regimen with a single oral dose of Mifepristone. <jats:italic>Conclusions<\/jats:italic>. Clinical management of IP remains a debated topic. In selected cases, a systemic multidose MTX regimen combined with a single oral dose of Mifepristone could be considered also in the presence of high serum <jats:italic>\u03b2<\/jats:italic>\u2010hCG.<\/jats:p>","DOI":"10.1155\/2020\/8703496","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T23:36:57Z","timestamp":1596497817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Conservative Treatment of Interstitial Ectopic Pregnancy with the Combination of Mifepristone and Methotrexate: Our Experience and Review of the Literature"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9266-3896","authenticated-orcid":false,"given":"Guglielmo","family":"Stabile","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Buonomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Zinicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8031-1102","authenticated-orcid":false,"given":"Giuseppe","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00442.x"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lers.2018.12.001"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.07.054"},{"key":"e_1_2_12_4_2","first-page":"1044","article-title":"Sonographic evolution of cornual pregnancies treated without surgery","volume":"79","author":"Timor-Tritsch I. 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