{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:51:09Z","timestamp":1790016669889,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201907630006"],"award-info":[{"award-number":["201907630006"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["2017KCXTD002"],"award-info":[{"award-number":["2017KCXTD002"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["2019A1515011443"],"award-info":[{"award-number":["2019A1515011443"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["31790411"],"award-info":[{"award-number":["31790411"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["31902165"],"award-info":[{"award-number":["31902165"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Team Project in Universities of Guangdong Province","award":["201907630006"],"award-info":[{"award-number":["201907630006"]}]},{"name":"Innovation Team Project in Universities of Guangdong Province","award":["2017KCXTD002"],"award-info":[{"award-number":["2017KCXTD002"]}]},{"name":"Innovation Team Project in Universities of Guangdong Province","award":["2019A1515011443"],"award-info":[{"award-number":["2019A1515011443"]}]},{"name":"Innovation Team Project in Universities of Guangdong Province","award":["31790411"],"award-info":[{"award-number":["31790411"]}]},{"name":"Innovation Team Project in Universities of Guangdong Province","award":["31902165"],"award-info":[{"award-number":["31902165"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["201907630006"],"award-info":[{"award-number":["201907630006"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017KCXTD002"],"award-info":[{"award-number":["2017KCXTD002"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515011443"],"award-info":[{"award-number":["2019A1515011443"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["31790411"],"award-info":[{"award-number":["31790411"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["31902165"],"award-info":[{"award-number":["31902165"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["201907630006"],"award-info":[{"award-number":["201907630006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017KCXTD002"],"award-info":[{"award-number":["2017KCXTD002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019A1515011443"],"award-info":[{"award-number":["2019A1515011443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31790411"],"award-info":[{"award-number":["31790411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902165"],"award-info":[{"award-number":["31902165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["201907630006"],"award-info":[{"award-number":["201907630006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2017KCXTD002"],"award-info":[{"award-number":["2017KCXTD002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019A1515011443"],"award-info":[{"award-number":["2019A1515011443"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31790411"],"award-info":[{"award-number":["31790411"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31902165"],"award-info":[{"award-number":["31902165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry","award":["201907630006"],"award-info":[{"award-number":["201907630006"]}]},{"name":"Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry","award":["2017KCXTD002"],"award-info":[{"award-number":["2017KCXTD002"]}]},{"name":"Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry","award":["2019A1515011443"],"award-info":[{"award-number":["2019A1515011443"]}]},{"name":"Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry","award":["31790411"],"award-info":[{"award-number":["31790411"]}]},{"name":"Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry","award":["31902165"],"award-info":[{"award-number":["31902165"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,5,25]]},"abstract":"<jats:p>\n                    Intrauterine growth restriction (IUGR) is associated with fetal mortality and morbidity. One of the most common causes of IUGR is placental insufficiency, including placental vascular defects, and mitochondrial dysfunction. In addition, a high level of oxidative stress induces placental vascular lesions. Here, we evaluated the oxidative stress status, mitochondrial function, angiogenesis, and nutrient transporters in placentae of piglets with different birth weights: &lt;500\u2009g (L), 500\u2013600\u2009g (LM), 600\u2013700\u2009g (M), and &gt;700\u2009g (H). Results showed that placentae from the L group had higher oxidative damage, lower adenosine triphosphate and citrate synthase levels, and lower vascular density, compared to those from the other groups. Protein expression of angiogenic markers, including vascular endothelial cadherin, vascular endothelial growth factor A, and platelet endothelial cell adhesion molecule-1, was the lowest in the L group placentae compared to the other groups. In addition, the protein levels of glucose transporters GLUT1 and GLUT3 were downregulated in the L group, compared to the other groups. Furthermore, oxidative stress induced by H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    inhibited tube formation and migration in porcine vascular endothelial cells. Collectively, placentae for lower birth weight neonates are vulnerable to oxidative damage, mitochondrial dysfunction, and impaired angiogenesis.\n                  <\/jats:p>","DOI":"10.1155\/2020\/8715412","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T19:32:03Z","timestamp":1590435123000},"page":"1-12","source":"Crossref","is-referenced-by-count":47,"title":["Placentae for Low Birth Weight Piglets Are Vulnerable to Oxidative Stress, Mitochondrial Dysfunction, and Impaired Angiogenesis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Chengjun","family":"Hu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Deng","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfang","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Yihao Foodstuffs Co., Ltd., Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Shu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Yin Yulong Academician Workstation, Yunnan Xinan Tianyou Animal Husbandry Technology Co., Ltd., Kunming, Yunnan 650032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhen","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Yin Yulong Academician Workstation, Yunnan Xinan Tianyou Animal Husbandry Technology Co., Ltd., Kunming, Yunnan 650032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-6975","authenticated-orcid":true,"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"},{"name":"National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, Hunan 410125, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9290-1807","authenticated-orcid":true,"given":"Chengquan","family":"Tan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong 510642, China"},{"name":"Department of Animal Science, Texas A&M University, College Station, Texas 77843-2471, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8058-6969","authenticated-orcid":true,"given":"Guoyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, Texas 77843-2471, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0732-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3587239"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1425834"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.03.004"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2012-5637"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2013-7388"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-156"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602552"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2010-2970"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skz379"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1725-z"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2018.09.002"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2009.02.005"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-003-0903-2"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12454"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22842"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0113-2"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4004(97)80061-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2018.09.002"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6661(200001\/02)9:1<79::AID-MFM16>3.0.CO;2-O"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-013-9750-1"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/826027"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2018.05.007"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.12.009"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2014.01.005"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122978"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.2527\/1999.7771654x"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.026344"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1186\/s12263-016-0535-1"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.10.015"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod64.6.1821"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.2527\/jas2017.1703"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2481592"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9194269"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8285065"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000055318.09997.1F"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7976382"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.09.012"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00426.2013"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1159\/000366079"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.12.029"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2004.00154.x"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/814543"},{"issue":"6","key":"44","first-page":"883","volume":"32","year":"2014","journal-title":"Clinical and Experimental Rheumatology"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-018-9638-1"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1593362"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/179827"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00344.2006"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0826"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.04.023"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.83"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-11-0355"},{"key":"53","year":"2018"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/8715412.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/8715412.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/8715412.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T19:32:09Z","timestamp":1590435129000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2020\/8715412\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,25]]},"references-count":53,"alternative-id":["8715412","8715412"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8715412","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,25]]}}}