{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:28:21Z","timestamp":1785767301417,"version":"3.56.0"},"reference-count":5,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Anesthesiology"],"published-print":{"date-parts":[[2020,6,10]]},"abstract":"<jats:p>On December 16, 2015, the Food and Drug Administration (FDA) in the United States approved sugammadex (Bridion, Merck and Co), a modified gamma-cyclodextrin, to be used as a reversal agent. It is a first and unique selective nondepolarizing steroidal muscle relaxant (NDSMR) binding agent with a great affinity for rocuronium and vecuronium. However, there have been several recently published case reports of bradycardia and asystole immediately after sugammadex administration for the reversal. This report presents a case of sugammadex administration followed by rapidly progressing bradycardia leading to asystole and subsequent death. The family has provided the written consent to share this case report.<\/jats:p>","DOI":"10.1155\/2020\/8767195","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T23:38:28Z","timestamp":1591832308000},"page":"1-2","source":"Crossref","is-referenced-by-count":7,"title":["Sugammadex-Associated Hypotension, Bradycardia, Asystole, and Death"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8310-4136","authenticated-orcid":true,"given":"Kazim","family":"Mirza","sequence":"first","affiliation":[{"name":"MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Landoski","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip","family":"Thakar","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagtar","family":"Heir-Singh","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Jackson","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Kassab","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2016.69.5.427"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjane.2018.09.006"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2709568"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1213\/xaa.0000000000000834"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2016.69.5.514"}],"container-title":["Case Reports in Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cria\/2020\/8767195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cria\/2020\/8767195.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cria\/2020\/8767195.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T23:38:29Z","timestamp":1591832309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cria\/2020\/8767195\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":5,"alternative-id":["8767195","8767195"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8767195","relation":{},"ISSN":["2090-6382","2090-6390"],"issn-type":[{"value":"2090-6382","type":"print"},{"value":"2090-6390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]}}}