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Therefore, the efficient denoising of ECG signals has become an important research topic. In the paper, we proposed an efficient ECG denoising approach based on empirical mode decomposition (EMD), sample entropy, and improved threshold function. This method can better remove the noise of ECG signals and provide better diagnosis service for the computer-based automatic medical system. The proposed work includes three stages of analysis: (1) EMD is used to decompose the signal into finite intrinsic mode functions (IMFs), and according to the sample entropy of each order of IMF following EMD, the order of IMFs denoised is determined; (2) the new threshold function is adopted to denoise these IMFs after the order of IMFs denoised is determined; and (3) the signal is reconstructed and smoothed. The proposed method solves the shortcoming of discarding the first-order IMF directly in traditional EMD denoising and proposes a new threshold denoising function to improve the traditional soft and hard threshold functions. We further conduct simulation experiments of ECG signals from the MIT-BIH database, in which three types of noise are simulated: white Gaussian noise, electromyogram (EMG), and power line interference. The experimental results show that the proposed method is robust to a variety of noise types. Moreover, we analyze the effectiveness of the proposed method under different input SNR with reference to improving SNR (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:msub>\n                           <a:mrow>\n                              <a:mtext>SNR<\/a:mtext>\n                           <\/a:mrow>\n                           <a:mrow>\n                              <a:mtext>imp<\/a:mtext>\n                           <\/a:mrow>\n                        <\/a:msub>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and mean square error (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>MSE<\/c:mtext>\n                     <\/c:math>\n                  <\/jats:inline-formula>), then compare the denoising algorithm proposed in this paper with previous ECG signal denoising techniques. The results demonstrate that the proposed method has a higher <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:msub>\n                           <e:mrow>\n                              <e:mtext>SNR<\/e:mtext>\n                           <\/e:mrow>\n                           <e:mrow>\n                              <e:mtext>imp<\/e:mtext>\n                           <\/e:mrow>\n                        <\/e:msub>\n                     <\/e:math>\n                  <\/jats:inline-formula> and a lower <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mtext>MSE<\/g:mtext>\n                     <\/g:math>\n                  <\/jats:inline-formula>. Qualitative and quantitative studies demonstrate that the proposed algorithm is a good ECG signal denoising method.<\/jats:p>","DOI":"10.1155\/2020\/8811962","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T02:50:15Z","timestamp":1608691815000},"page":"1-11","source":"Crossref","is-referenced-by-count":45,"title":["An Efficient ECG Denoising Method Based on Empirical Mode Decomposition, Sample Entropy, and Improved Threshold Function"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2789-2980","authenticated-orcid":true,"given":"Dengyong","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Computer and Communication Engineering, Changsha University of Science and Technology, 410114, China"},{"name":"Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation, Changsha University of Science and Technology, Changsha, 410114 Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Computer and Communication Engineering, Changsha University of Science and Technology, 410114, China"},{"name":"Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation, Changsha University of Science and Technology, Changsha, 410114 Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Computer and Communication Engineering, Changsha University of Science and Technology, 410114, China"},{"name":"Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation, Changsha University of Science and Technology, Changsha, 410114 Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2719-9470","authenticated-orcid":true,"given":"Shang","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Computer and Communication Engineering, Changsha University of Science and Technology, 410114, China"},{"name":"Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation, Changsha University of Science and Technology, Changsha, 410114 Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Computer and Communication Engineering, Changsha University of Science and Technology, 410114, China"},{"name":"Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation, Changsha University of Science and Technology, Changsha, 410114 Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangling","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Hunan University of Science and Technology, Xiangtan 411004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Gong","sequence":"additional","affiliation":[{"name":"Changsha Social Work College, Changsha 410004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/cpe.5553"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1109\/10.43620"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2019.101788"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2019.2912036"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1109\/ICOSP.2004.1442214"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1109\/iembs.2001.1019561"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1098\/rspa.1998.0193"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1109\/18.382009"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2013.07.030"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3109\/03091902.2014.979954"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s13534-015-0182-2"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2013.05.001"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/81.3.425"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA13202F"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2005.855719"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.6.h2039"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00069.2002"},{"issue":"2","key":"18","first-page":"182","article-title":"Adaptive wavelet denoising method based on sample entropy","volume":"22","author":"X. 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