{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:19:50Z","timestamp":1784567990938,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":321,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074521"],"award-info":[{"award-number":["82074521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. As a noninvasive and nonpharmacological therapeutic approach, superficial acupuncture (SA) is a special method of acupuncture. In this study, using nonlinear dynamics and multivariate statistics, we studied the electroencephalography (EEG) of primary insomnia under SA intervention to investigate how brain regions change. <jats:italic>Method<\/jats:italic>. This study included 30 adults with primary insomnia. They underwent superficial acupuncture at the Shangen acupoint. The EEG signals were collected for 10 minutes at each state, including the resting state, the intervention state, and the postintervention state. The data were conducted using nonlinear dynamics (including approximate entropy (ApEn) and correlation dimension (CD)) and multivariate statistics. <jats:italic>Result<\/jats:italic>. The repeated\u2010measures ANOVA results showed that both ApEn and CD values were not significantly different at the three states (<jats:italic>p<\/jats:italic> &gt; 0.05). The paired <jats:italic>t<\/jats:italic>\u2010test results showed that the ApEn values of electrodes O2 (the right occipital lobe) at the postintervention state have decreased, compared with the resting state (<jats:italic>p<\/jats:italic> &lt; 0.05), and no difference was detected in CD (<jats:italic>p<\/jats:italic> &gt; 0.05). The cluster analysis results of ApEn showed that patients\u2019 EEG has changed from the right prefrontal lobe (electrode Fp2) to the right posterior temporal lobe (electrode T6) and finally to the right occipital lobe (electrode O2), before, during, and after the SA intervention. In addition, the factor analysis results of CD revealed that patients\u2019 EEG of all brain regions except for the occipital lobes has changed to the frontal lobes and anterior temporal and frontal lobes from pre\u2010 to postintervention. <jats:italic>Conclusion<\/jats:italic>. SA activated the corresponding brain regions and reduced the complexity of the brain involved. It is feasible to use nonlinear dynamics analysis and multivariate statistics to examine the effects of SA on the human brain.<\/jats:p>","DOI":"10.1155\/2020\/8817843","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T20:56:27Z","timestamp":1605646587000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Using Nonlinear Dynamics and Multivariate Statistics to Analyze EEG Signals of Insomniacs with the Intervention of Superficial Acupuncture"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8585-2661","authenticated-orcid":false,"given":"Shi-Yi","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-4431","authenticated-orcid":false,"given":"Dong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9706-2835","authenticated-orcid":false,"given":"Xiao-Zhen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3901-9393","authenticated-orcid":false,"given":"Shen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5765-6401","authenticated-orcid":false,"given":"Chuan-Hai","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-1664","authenticated-orcid":false,"given":"Zhi-Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000009471"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2017-011520"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12319"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2013.04.001"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3651268"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-403"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2017-011371"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009594"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2014.05.002"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.04.002"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196933"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1204709"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.2407"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.28048"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.04.046"},{"key":"e_1_2_9_16_2","first-page":"869","article-title":"Sleep disorder of schizophrenia treated with shallow needling: a randomized controlled trial","volume":"35","author":"Huang Y.","year":"2015","journal-title":"Zhongguo Zhen Jiu\u2009=\u2009Chinese Acupuncture & Moxibustion"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.13702\/j.1000-0607.170614"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6123"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2014.11.008"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9080201"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2013.08.014"},{"key":"e_1_2_9_22_2","unstructured":"!!! 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