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Diseases","doi-asserted-by":"publisher","award":["U01AI125003"],"award-info":[{"award-number":["U01AI125003"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2020,10,29]]},"abstract":"<jats:p>\n                    Background. Though peripheral blood is a crucial sample to study immunology, it is unclear whether the immune environment in the peripheral vasculature correlates with that at the end-organ site of infection. Using cryptococcal meningitis as a model, we investigated the correlation between serum and cerebrospinal fluid biomarkers over time. Methods. We analyzed the cerebrospinal fluid and serum of 160 subjects presenting with first episode cryptococcal meningitis for soluble cytokines and chemokines measured by Luminex assay. Specimens were collected at meningitis diagnosis, 1-week, and 2-week post cryptococcal diagnosis. We compared paired samples by Spearman\u2019s correlation and the\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    value was set at &lt;0.01. Results. Of the 21 analytes tested at baseline, there was no correlation detected between nearly all analytes. A weak negative correlation was found between serum and cerebrospinal fluid levels of interferon-gamma (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>Rho<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mo>\u2212<\/c:mo>\n                        <c:mn>0.214<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ;\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>.007<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ) and interleukin-4 (\n                    <jats:inline-formula>\n                      <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mtext>Rho<\/g:mtext>\n                        <g:mo>=<\/g:mo>\n                        <g:mo>\u2212<\/g:mo>\n                        <g:mn>0.232<\/g:mn>\n                      <\/g:math>\n                    <\/jats:inline-formula>\n                    ;\n                    <jats:inline-formula>\n                      <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>.003<\/i:mn>\n                      <\/i:math>\n                    <\/jats:inline-formula>\n                    ). There was no correlation at 1-week post cryptococcal diagnosis. However, at 2-week post cryptococcal diagnosis, there was a weak positive correlation of granulocyte-macrophage colony-stimulating factor levels (\n                    <jats:inline-formula>\n                      <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mtext>Rho<\/k:mtext>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.25<\/k:mn>\n                      <\/k:math>\n                    <\/jats:inline-formula>\n                    ;\n                    <jats:inline-formula>\n                      <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>.007<\/m:mn>\n                      <\/m:math>\n                    <\/jats:inline-formula>\n                    ) in serum and cerebrospinal fluid. No cytokine or chemokine showed consistent correlation overtime. Conclusion. Based on our analysis of 21 biomarkers, serum and cerebrospinal fluid immune responses do not correlate. There appears to be a distinct immune environment in terms of soluble biomarkers in the vasculature versus end-organ site of infection. While this is a model of HIV-related cryptococcal meningitis, we postulate that assuming the blood compartment is representative of the immune function at the end-organ site of infection may not be appropriate.\n                  <\/jats:p>","DOI":"10.1155\/2020\/8818044","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T23:20:08Z","timestamp":1604013608000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1495-4596","authenticated-orcid":true,"given":"Elizabeth C.","family":"Okafor","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Minnesota, 55455 Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2754-3473","authenticated-orcid":true,"given":"Katherine H.","family":"Hullsiek","sequence":"additional","affiliation":[{"name":"School of Public Health, University of Minnesota, 55455 Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-5060","authenticated-orcid":true,"given":"Darlisha A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota, 55455 Minneapolis, MN, USA"},{"name":"Infectious Diseases Institute, Makerere University, P.O. Box 22418 Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-7137","authenticated-orcid":true,"given":"James E.","family":"Scriven","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, and Department of Medicine, Observatory 7925 University of Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-9646","authenticated-orcid":true,"given":"Joshua","family":"Rhein","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota, 55455 Minneapolis, MN, USA"},{"name":"Infectious Diseases Institute, Makerere University, P.O. Box 22418 Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0351-507X","authenticated-orcid":true,"given":"Henry W.","family":"Nabeta","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, P.O. Box 22418 Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-5344","authenticated-orcid":true,"given":"Abdu K.","family":"Musubire","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, P.O. 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Box 22418 Kampala, Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4715-0060","authenticated-orcid":true,"given":"David R.","family":"Boulware","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Minnesota, 55455 Minneapolis, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-012513-104653"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/jof4010025"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312884"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv067"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.039123"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00167-11"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu664"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(96)00214-7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0683LE"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004701"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.8.5367"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.40.1.21.26"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090634"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2020\/8818044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2020\/8818044.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2020\/8818044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T23:20:10Z","timestamp":1604013610000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2020\/8818044\/"}},"subtitle":[],"editor":[{"given":"Mirella","family":"Giovarelli","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":13,"alternative-id":["8818044","8818044"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8818044","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.08.20095232","asserted-by":"object"}]},"ISSN":["1466-1861","0962-9351"],"issn-type":[{"value":"1466-1861","type":"electronic"},{"value":"0962-9351","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,29]]}}}