{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:38:18Z","timestamp":1792103898272,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":343,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860112"],"award-info":[{"award-number":["81860112"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Perfluorooctane sulfonate (PFOS), an environmentally persistent pollutant, has been revealed to elicit hepatic toxicity. In the current study, we investigated the protective role of grape seed proanthocyanidin extract (GSPE) against PFOS\u2010caused steatohepatitis in mice. Animals were exposed intragastrically to PFOS (10\u2009mg\/kg\/day), GSPE (150\u2009mg\/kg\/day), or their combination. After 21 days of treatment, mice exposed to PFOS exhibited steatosis, oxidative stress, and inflammation in the liver. Nevertheless, simultaneous administration of GSPE resumed the declined serum hepatic enzyme activities and histological abnormalities in PFOS\u2010exposed mice. Furthermore, GSPE supplementation reduced the contents of triglyceride (TG) and total cholesterol (TC) and expression of lipid metabolism\u2010associated genes <jats:italic>CD36<\/jats:italic> and fatty acid\u2010binding protein 4 (<jats:italic>FABP4<\/jats:italic>) in the liver of mice treated with PFOS. Moreover, GSPE suppressed the generation of lipid peroxidative product malondialdehyde and restored the activity of superoxide dismutase in the liver of PFOS\u2010exposed mice. In addition, GSPE repressed the PFOS\u2010induced hepatic overproduction of proinflammatory cytokines interleukin\u20106 (IL\u20106) and tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>). Our results demonstrate that GSPE attenuates PFOS\u2010caused steatohepatitis in mice by regulating lipid metabolism, oxidative stress, and inflammatory response.<\/jats:p>","DOI":"10.1155\/2020\/8818160","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T08:10:42Z","timestamp":1607587842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Attenuation of Perfluorooctane Sulfonate\u2010Induced Steatohepatitis by Grape Seed Proanthocyanidin Extract in 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