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Although there have been some advances in the treatment of sepsis, mortality rates remain high, urging for the search of new therapies. \u03b2-Lapachone (\u03b2-Lap) is a natural compound obtained from Tabebuia avellanedae Lorentz ex Griseb. with several pharmacological properties including bactericidal, anti-inflammatory, and antioxidant activity. Thus, the aim of this study was to evaluate the effects of \u03b2-Lap in a mouse sepsis model. To this, we tested two therapeutic protocols in mice submitted to cecal ligation and puncture- (CLP-) induced sepsis. First, we found that in pretreated animals, \u03b2-Lap reduced the systemic inflammatory response and improved bacterial clearance and mouse survival. Moreover, \u03b2-Lap also decreased lipid peroxidation and increased the total antioxidant capacity in the serum and peritoneal cavity of septic animals. In the model of severe sepsis, the posttreatment with \u03b2-Lap was able to increase the survival of animals and maintain the antioxidant defense function. In conclusion, the \u03b2-Lap was able to increase the survival of septic animals by a mechanism involving immunomodulatory and antioxidant protective effects.<\/jats:p>","DOI":"10.1155\/2020\/8820651","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T03:20:09Z","timestamp":1607829609000},"page":"1-12","source":"Crossref","is-referenced-by-count":1,"title":["\u03b2-Lapachone Increases Survival of Septic Mice by Regulating Inflammatory and Oxidative Response"],"prefix":"10.1155","volume":"2020","author":[{"given":"Ana L.","family":"de B. 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