{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:29:23Z","timestamp":1764332963207,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2020,11,28]]},"abstract":"<jats:p>The aim of study was to compare patients with hypertrophic cardiomyopathy divided according to septal configuration assessed in a 4-chamber apical window. The study group consisted of 56 consecutive patients. Reversed septal curvature (RSC) and non-RSC were diagnosed in 17 (30.4%) and 39 (69.6%) patients, respectively. Both RSC and non-RSC groups were compared in terms of the level of high-sensitivity troponin I (hs-TnI), NT-proBNP (absolute value), NT-proBNP\/ULN (value normalized for sex and age), and echocardiographic parameters, including left ventricular outflow tract gradient (LVOTG). A higher level of hs-TnI was observed in RSC patients as compared to the non-RSC group (102 (29.2-214.7) vs. 8.7 (5.3-18) (ng\/l), <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). A trend toward increased NT-proBNP value was reported in RSC patients (1279 (367.3-1186) vs. 551.7 (273-969) (pg\/ml), <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.056<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). However, no difference in the NT-proBNP\/ULN level between both groups was observed. Provocable LVOTG was higher in RSC as compared to non-RSC patients (51 (9.5-105) vs. 13.6 (7.5-31) (mmHg), <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.04<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Furthermore, more patients with RSC had prognostically unfavourable increased septal thickness to left LV diameter at the end diastole ratio. Patients with RSC were associated with an increased level of hs-TnI, and the only trend observed in this group was for the higher NT-proBNP levels. RSC seems to be an alerting factor for the risk of ischemic events. Not resting but only provocable LVOTG was higher in RSC as compared to non-RSC patients.<\/jats:p>","DOI":"10.1155\/2020\/8821961","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T03:20:05Z","timestamp":1606620005000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Reversed Septal Curvature Is Associated with Elevated Troponin Level in Hypertrophic Cardiomyopathy"],"prefix":"10.1155","volume":"2020","author":[{"given":"Renata","family":"Rajtar-Salwa","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiovascular Interventions, University Hospital, Jakubowskiego 2 St., 30-688 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0836-1877","authenticated-orcid":true,"given":"Tomasz","family":"Tokarek","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Cardiovascular Interventions, University Hospital, Jakubowskiego 2 St., 30-688 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7239-9044","authenticated-orcid":true,"given":"Pawe\u0142 Petkow","family":"Dimitrow","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, 31-501 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.05.031"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6487152"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-017-0115-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80159-6"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.4.766"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90771-P"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.030353"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2008.00851.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1575130"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.15130"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.01.025"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.5114\/aic.2018.76413"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.12.009"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.3.580"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90222-B"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04005-8"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006153422403"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.08.1057"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9417908"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90273-9"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy806"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2020\/8821961.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2020\/8821961.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2020\/8821961.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T03:20:07Z","timestamp":1606620007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2020\/8821961\/"}},"subtitle":[],"editor":[{"given":"Agata","family":"Sakowicz","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,28]]},"references-count":22,"alternative-id":["8821961","8821961"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8821961","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"type":"electronic","value":"1875-8630"},{"type":"print","value":"0278-0240"}],"subject":[],"published":{"date-parts":[[2020,11,28]]}}}