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Increasing evidence has revealed that mesenchymal stromal cell (MSC) transplantation alleviates hypoxic-ischemic brain damage (HIBD) induced neurological impairments via immunomodulating astrocyte antiapoptosis effects. However, it remains unclear whether MSCs regulate neuron autophagy following HIBD. Results. In the present study, MSC transplantation effectively ameliorated learning-memory function and suppressed stress-induced hippocampal neuron autophagy in HIBD rats. Moreover, the suppressive effects of MSCs on autophagy were significantly weakened following endogenous IL-6 silencing in MSCs. Suppressing IL-6 expression also significantly increased p-AMPK protein expression and decreased p-mTOR protein expression in injured hippocampal neurons. Conclusion. Endogenous IL-6 in MSCs may reduce autophagy in hippocampal neurons partly through the AMPK\/mTOR pathway.<\/jats:p>","DOI":"10.1155\/2020\/8822579","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T01:06:06Z","timestamp":1598663166000},"page":"1-12","source":"Crossref","is-referenced-by-count":11,"title":["Mesenchymal Stromal Cells Suppress Hippocampal Neuron Autophagy Stress Induced by Hypoxic-Ischemic Brain Damage: The Possible Role of Endogenous IL-6 Secretion"],"prefix":"10.1155","volume":"2020","author":[{"given":"Miao","family":"Yang","sequence":"first","affiliation":[{"name":"Children\u2019s Nutrition Research Center, Children\u2019s Hospital of Chongqing Medical University, Chongqing 400014, China"},{"name":"Chongqing Key Laboratory of Child Nutrition and Health, Chongqing 400014, China"},{"name":"Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing 400014, China"},{"name":"China International Science and 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