{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:05:55Z","timestamp":1771333555942,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2020,9,22]]},"abstract":"<jats:p>Fear of injection-related pain is a drawback to injectable therapy. Hypodermic injections are a cause for great anxiety and reduced adherence to the subcutaneous application of insulin for glycemic control in diabetics or in the treatment of multiple sclerosis, increasing the risk of complications and mortality. Injured or sick people have to undergo several daily injections, forcing them to rotate the veins and regions used to recover from the trauma caused by the perforation of the skin, tissue, muscles, veins, and arteries. People who suffer from type 1 diabetes mellitus (DM1) need to have their glycemic control 3 to 5 times a day and to take insulin up to 3 times a day. In both cases, the patient needs to perforate the skin. To quantify the pain perceived by the patients depends on the evaluation of each patient and therefore is subjective. This study aims to understand the application and self-application of hypodermic injections and decrease pain during its application and the phobia of the patient, following the reasoning that the lower the effort to penetrate the needle, the less trauma in the tissue and therefore the pain provoked. For that, it was analyzed how some of the characteristics of the needle can influence the sensation of pain in the injection. The needle penetration effort was measured in an artificial tissue (substitute skin model) for different cannula diameters, roughness, depth of penetration, lubrication, and angles of the perforating tip bevel. This study aimed to find alternatives to facilitate the application and self-application of hypodermic injections, increase safety and comfort, and reduce the pain intensity perceived by the patient. To do this, the bevel of needles used repeatedly was analyzed in the profile projector and SEM to verify the loss of the profile or the formation of burrs that could hamper the penetration or traumatize the tissue during the reuse of needles. It has also been mechanically analyzed, which can be done to prevent that the needles used in the subcutaneous application do not inadvertently reach the muscle. The greater penetration effort observed in the needles with greater angle of the bevel is responsible for the patient\u2019s perception of pain.<\/jats:p>","DOI":"10.1155\/2020\/8822686","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:15:54Z","timestamp":1600820154000},"page":"1-12","source":"Crossref","is-referenced-by-count":12,"title":["Variation of the Penetration Effort in an Artificial Tissue by Hypodermic Needles"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5376-3392","authenticated-orcid":true,"given":"Aparecido Carlos","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering (DEM), FEIS, University of State of Sao Paulo (UNESP), Ilha Solteira, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidnei","family":"Cavassana","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, (DEM), FEIS, UNESP, Ilha Solteira, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1203-7586","authenticated-orcid":true,"given":"F\u00e1bio R.","family":"Chavarette","sequence":"additional","affiliation":[{"name":"Department of Mathematics, (MAT), FEIS, UNESP, Ilha Solteira, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Outa","sequence":"additional","affiliation":[{"name":"Department of Biofuels, Ara\u00e7atuba Technology College, FATEC, Sorocaba, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel J.","family":"Casarin","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, (DEM), FEB, UNESP, Bauru, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalberto Vieira","family":"Corazza","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Campus of Tr\u00eas Lagoas (CPTL), Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2011.0010"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1177\/193229680700100517"},{"key":"3","year":"2010"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1177\/193229681200600217"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2016-000266"},{"issue":"2","key":"7","first-page":"204","volume":"55","year":"2016","journal-title":"Journal of the American Association for Laboratory Animal Science: JAALAS"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1243\/0954411971534467"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2006.09.005"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1109\/tbme.2009.2036856"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216441109"},{"key":"12","year":"2003"},{"key":"13","year":"2014"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1177\/193229681200600216"}],"container-title":["Journal of Healthcare Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2020\/8822686.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2020\/8822686.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jhe\/2020\/8822686.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:15:56Z","timestamp":1600820156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/jhe\/2020\/8822686\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":13,"alternative-id":["8822686","8822686"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8822686","relation":{},"ISSN":["2040-2295","2040-2309"],"issn-type":[{"value":"2040-2295","type":"print"},{"value":"2040-2309","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,22]]}}}