{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:53:57Z","timestamp":1775908437134,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry Research International"],"published-print":{"date-parts":[[2020,9,18]]},"abstract":"<jats:p><jats:italic>Thymus leptobotrys<\/jats:italic> is a medicinal plant belonging to the Lamiaceae family, endemic in Morocco, and used in traditional medicine. The present work aims to study the phenolic compounds, the antioxidant activity, the anti-inflammatory effect, and the toxicity of two ethanolic and methanolic extracts of <jats:italic>Thymus leptobotrys<\/jats:italic> aerial part. The yield of the methanolic extraction (22.2%) is higher than that of the ethanolic extraction (15.8%) and is characterized by higher contents of polyphenols 243.08\u2009mg\/g GAE (mg\/g of gallic acid), flavonoids 179.28\u2009mg\/g RE (mg\/g of rutin), and tannins 39.31\u2009mg\/g CE (mg\/g of catechin). The <jats:italic>in vitro<\/jats:italic> measurement of antioxidant activity with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical reduction test and Trolox equivalent antioxidant capacity (TEAC) test demonstrates the higher performance of the methanolic extract. The evaluation of the anti-inflammatory effect <jats:italic>in vivo<\/jats:italic> on adult Wistar female rats leads to a very significant decrease in the inflammation of the edema compared to the standard drug (indomethacin) and the control group. The toxicity test reveals that both extracts showed no toxicity within an LD50 above 2000\u2009mg\/kg body weight of the rats.<\/jats:p>","DOI":"10.1155\/2020\/8823209","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T23:32:51Z","timestamp":1600471971000},"page":"1-7","source":"Crossref","is-referenced-by-count":18,"title":["Phenolic Content, Antioxidant Activity, Anti-Inflammatory Potential, and Acute Toxicity Study of <i>Thymus leptobotrys<\/i> Murb. 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