{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:37:43Z","timestamp":1765546663317,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":244,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Salivary gland tumors (SGT) comprise 3% of all head and neck tumors, are mostly benign, and arise frequently in the parotid gland. Pleomorphic adenoma (PA) is the commonest SGT, representing 60\u201070% of all benign parotid tumors. Clinically, parotid PA presents as irregular, lobulated, asymptomatic, slow\u2010growing preauricular mass, involving both superficial and deep lobes, and could grow to gigantic proportions. Histologically, PA has epithelial and mesenchymal elements in chondromyxoid matrix and is managed surgically. Based on a review of 43 cases reported in English literature since 1995, giant parotid PA is reported as large as 35\u2009cm (diameter) and 7.3\u2009kg (resected weight). Although rare, 10 cases of malignant transformation were reported in the review. Surgical management included extracapsular dissection (ECD), superficial parotidectomy, and total parotidectomy for benign tumors, and adjuvant radiation or chemotherapy for malignant tumors. We further present the case of a 36\u2010year\u2010old healthy male with slow\u2010growing and asymptomatic giant parotid PA, of 4\u2010year duration. The patient presented with firm, lobulated preauricular swelling, provisionally diagnosed as PA based on radiographic and cytological findings. The tumor was resected through ECD, and the patient had uneventful postoperative recovery and a 7\u2010year recurrence\u2010free follow\u2010up period. Histological examination revealed epimyoepithelial proliferation punctuated by chondromyxoid areas, with extensive squamous metaplasia and keratin cysts. To the best of knowledge from indexed literature, giant parotid PA is rarely reported in Saudi Arabia. In addition to its rarity, this case is reported for its benign nature despite atypical histological presentation, successful surgical management without complications, and long\u2010term recurrence\u2010free follow\u2010up. Based on this report, clinicians must be aware of atypical histological presentations associated with PA and plan suitable surgical management and follow\u2010up to avoid morbidity. Nevertheless, attempts must be made to diagnose and manage these lesions at an early stage and before they reach gigantic proportions.<\/jats:p>","DOI":"10.1155\/2020\/8828775","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T19:33:08Z","timestamp":1598988788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Giant Parotid Pleomorphic Adenoma with Atypical Histological Presentation and Long\u2010Term Recurrence\u2010Free Follow\u2010Up after Surgery: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-5350","authenticated-orcid":false,"given":"Mohammed","family":"AlKindi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-5379","authenticated-orcid":false,"given":"Sundar","family":"Ramalingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-8707","authenticated-orcid":false,"given":"Lujain Abdulmajeed","family":"Hakeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-579X","authenticated-orcid":false,"given":"Manal A.","family":"AlSheddi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2017.1618"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.4317\/jced.55685"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2019.08.007"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.188694"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-222249"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2018.07.15"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2019.08.008"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(96)80023-0"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556139607500704"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556139807700812"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2000.9587"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0266435602002462"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.10165"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ooe.2003.12.006"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sap.0000176023.94693.b7"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.11.026"},{"key":"e_1_2_8_17_2","first-page":"261","article-title":"Giant deep lobe parotid gland pleomorphic adenoma involving the parapharyngeal space. 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