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Time-Kill kinetics of these combinations were then analyzed to find collateral bactericidal combinations which were then tested on other randomly selected MRSA isolates. Among the top 5 combinations including levofloxacin-ceftazidime; amoxicillin\/clavulanic acid-tobramycin; amoxicillin\/clavulanic acid-cephradine; amoxicillin\/clavulanic acid-ofloxacin; and piperacillin\/tazobactam-tobramycin, three combinations were found to be collaterally effective. Levofloxacin-ceftazidime acted synergistically in 80% of the tested clinical MRSA isolates. First-line \u03b2-lactams of lower generations can be used effectively against MRSA infection when used in combination. 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