{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:39:49Z","timestamp":1747190389706,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"crossref","award":["0529-2019-0056"],"award-info":[{"award-number":["0529-2019-0056"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Toxicology"],"published-print":{"date-parts":[[2020,11,21]]},"abstract":"<jats:p>The modeling of adaptation potential decrease in rats due to modification of the diet\u2019s vitamin\u2013mineral composition allows to increase animals\u2019 sensitivity to toxic load in reprotoxicological experiments. The threshold values of vitamins B1, B2, B3, and B6 and mineral substances Fe3+ and Mg2+ in the diet, which lead to a considerable reduction of laboratory animals\u2019 adaptation potential, have been determined as 19% (from the basic level in the diet) for males and 18% for females. The efficiency of this model has been confirmed in a reprotoxicological experiment with glyphosate as a toxic factor: the action of the toxic factor against the background of reduced availability of B vitamins and salts Fe3+ and Mg2+ led to significant changes in such indicators of reproductive function as mating efficiency, postimplantation loss, and the total number of alive pups, while the toxic effect of glyphosate was not so pronounced against the normal level of essential substances. The obtained results prove that this adaptation potential reduction model can be recommended for the research of the low-toxicity objects reproductive toxicity in rats and for the safety assessment of novel food, in particular.<\/jats:p>","DOI":"10.1155\/2020\/8834630","type":"journal-article","created":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T01:50:08Z","timestamp":1606009808000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["The Use of the Adaptation Potential Reduction Model for Reproductive Toxicity Research In Vivo"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-5327","authenticated-orcid":true,"given":"Nadezhda V.","family":"Tyshko","sequence":"first","affiliation":[{"name":"Federal State Budgetary Scientific Institution, Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira O.","family":"Sadykova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution, Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-4134","authenticated-orcid":true,"given":"Svetlana I.","family":"Shestakova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution, Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolay S.","family":"Nikitin","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution, Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina D.","family":"Trebukh","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution, Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Loginova","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution, Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina A.","family":"Pashorina","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution, Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentin M.","family":"Zhminchenko","sequence":"additional","affiliation":[{"name":"Federal State Budgetary Scientific Institution, Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"348","article-title":"Development of the controlled level of adaptation for toxicological studies","volume":"8","author":"N. 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