{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T16:58:09Z","timestamp":1784912289710,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":328,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","award":["NMUB2018019"],"award-info":[{"award-number":["NMUB2018019"]}],"id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Obesity is directly associated with the risk of cancer in different organs, including breast, colon, and kidney. However, adipocytes could be utilized to control progression for some types of cancer, such as leukemia and breast cancer. To explore the potential correlation between adipocytes and cancer, the combined effect of expression levels of obesity\u2010related genes and clinical factors (i.e., gender, race, menopausal status, history of smoking, tumor grade, body mass index (BMI), and history of drinking) on cancer survival rate was systemically studied. The expression levels of obesity\u2010related genes in cancer tissues and normal tissues were downloaded from The Cancer Genome Atlas (TCGA). Kaplan\u2013Meier curves were plotted using R programming language. The log\u2010rank test was applied to explore the correlation between different clinical subgroups. The overexpression of the nine obesity\u2010related genes (<jats:italic>MC4R<\/jats:italic>, <jats:italic>TMEM18<\/jats:italic>, <jats:italic>KCTD15<\/jats:italic>, <jats:italic>GNPDA2<\/jats:italic>, <jats:italic>SH2B1<\/jats:italic>, <jats:italic>MTCH2<\/jats:italic>, <jats:italic>FTO<\/jats:italic>, <jats:italic>PCSK1<\/jats:italic>, and <jats:italic>GPR120<\/jats:italic>) may associate with tumor\u2010promoting factors in some organs (head and neck, gastrointestinal tract, liver, and gallbladder). Underexpressed <jats:italic>LEPR<\/jats:italic>, <jats:italic>NEGR1<\/jats:italic>, <jats:italic>TMEM18<\/jats:italic>, and <jats:italic>SH2B1<\/jats:italic> genes prevented the progression and metastasis of kidney cancer. The combined effect of clinical factors and the expression levels of obesity\u2010related genes on patients\u2019 survival was found to be significant. Our outcomes suggested that the alternations of DNA methylation patterns could result in the changes of expression levels of obesity\u2010related genes, playing a critical role in tumor progression. The results of the current study may be utilized to supplement precision and personalized medicine, as well as provide novel insights for the development of treatment approaches for cancer.<\/jats:p>","DOI":"10.1155\/2020\/8838676","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T01:20:26Z","timestamp":1606267226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Combined Effect of Expression Levels of Obesity\u2010Related Genes and Clinical Factors on Cancer Survival 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