{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T18:22:58Z","timestamp":1766514178607,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Critical Care"],"published-print":{"date-parts":[[2020,12,24]]},"abstract":"<jats:p>Calcium channel blocker (CCB) poisoning frequently presents with cardiovascular complications such as cardiogenic shock and arrhythmia. We present a case of massive verapamil overdose causing refractory noncardiogenic pulmonary edema successfully treated with extracorporeal membrane oxygenation. To our knowledge, this is the first case with these features reported in literature. A 27-year-old female patient presented with an overdose of 18,000\u2009mg of verapamil. Her clinical condition deteriorated to severe hypoxic respiratory failure despite being treated with calcium, high-dose insulin, and full invasive ventilation support. She eventually required venovenous extracorporeal membrane oxygenation (VV-ECMO) for three days with full recovery. Large ingestion of verapamil could lead to noncardiogenic pulmonary edema. VV-ECMO might play an important role to support the treatment in severe cases with refractory hypoxia.<\/jats:p>","DOI":"10.1155\/2020\/8842303","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T19:05:09Z","timestamp":1609182309000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Severe Noncardiogenic Pulmonary Edema Secondary to Massive Verapamil Overdose and Treatment with Venovenous Extracorporeal Membrane Oxygenation"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3155-7568","authenticated-orcid":true,"given":"An","family":"Ho","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care, Saint Louis University Hospital, St. Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Saint Louis University Hospital, St. Louis Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Barrios","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care, Saint Louis University Hospital, St. Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Scalzo","sequence":"additional","affiliation":[{"name":"Toxicology, Department of Internal Medicine, Saint Louis University Hospital, St. Louis, Missouri, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","article-title":"Calcium channel blocker poisoning","volume-title":"UpToDate","author":"F. 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