{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:28:59Z","timestamp":1778009339925,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T00:00:00Z","timestamp":1605225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2020,11,13]]},"abstract":"<jats:p>Background. One of the most dangerous Plasmodium species is Plasmodium falciparum. Hence, it causes a higher rate of mortality. The resistance of Plasmodium falciparum to the ACT (Artemisinin-based Combination Therapies) has led to the search for new antimalarial drugs. The purpose of this research was to assess the in vivo antiplasmodial activity of Entandrophragma cylindricum ethyl acetate extract to provide a scientific basis for the use of this medicinal plant to treat malaria. Methods. Entandrophragma cylindricum stem bark powder was macerated in ethyl acetate to obtain the extract. The extract liquid filtrate was concentrated, evaporated and dry using a Rotavapor. The Peter and Rane test were used for the suppressive and curative antiplasmodial activities at different doses (125, 250 and 500\u2009mg\/kg). A positive and negative control groups were administered chloroquine (5\u2009mg\/kg) and 10% hypromelose, respectively. To assess the parasitemia of the mice a thin blood smear was made. Results. The ethyl acetate extract completely (100%) inhibited the development of P. berghei in the suppressive test at the dose of 500\u2009mg\/kg while that of the curative test was inhibited at 95%. The extract-treated group (500\u2009mg\/kg) and (Chloroquine (5\u2009mg\/kg) group all survived. The negative control group recorded a 100% mortality rate. Conclusion. The present study provides scientific confirmation on the use of E. cylindricum stem bark as an antiplasmodial remedy. However, the identification of the mode of action and the purification of the active compounds are necessary for further studies.<\/jats:p>","DOI":"10.1155\/2020\/8846067","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T01:50:08Z","timestamp":1605577808000},"page":"1-7","source":"Crossref","is-referenced-by-count":2,"title":["In Vivo Antiplasmodial Activity of Entandrophragma cylindricum (Sprague) Sprague Ethyl Acetate Extract in Plasmodium berghei-Infected Mice"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-9841","authenticated-orcid":true,"given":"Noumedem Anangmo Christelle","family":"Nadia","sequence":"first","affiliation":[{"name":"Department of Microbiology, Haematology and Immunology Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, P.O. Box 96, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7558-4296","authenticated-orcid":true,"given":"Yamssi","family":"C\u00e9dric","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, University of Bamenda, P.O. Box 39 Bambili, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngongang Ouankou","family":"Christian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, P.O. Box 96, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5050-566X","authenticated-orcid":true,"given":"Simeni Njonnou Sylvain","family":"Raoul","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Specialties, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, P.O. Box 96, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yondo","family":"Jeanette","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Haematology and Immunology Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, P.O. Box 96, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounvera","family":"Abdel Azizi","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 067, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8994-0004","authenticated-orcid":true,"given":"Sop Foka Eric","family":"Igor","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 067, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djape Guangue","family":"Diane","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 067, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chahdini Gbambie","family":"Abass","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 067, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsila Henri","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 067, Dschang, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mpoame","family":"Mbida","sequence":"additional","affiliation":[{"name":"Department of Animal Biology, Faculty of Science, University of Dschang, P.O. 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