{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:59:19Z","timestamp":1768283959568,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T00:00:00Z","timestamp":1607990400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C1324"],"award-info":[{"award-number":["HI14C1324"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["6-2019-0184"],"award-info":[{"award-number":["6-2019-0184"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI14C1324"],"award-info":[{"award-number":["HI14C1324"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["6-2019-0184"],"award-info":[{"award-number":["6-2019-0184"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["HI14C1324"],"award-info":[{"award-number":["HI14C1324"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6-2019-0184"],"award-info":[{"award-number":["6-2019-0184"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:p>Serum amyloid A (SAA) is one of the acute phase proteins synthesized in hepatocytes and secreted by various inflammation or infectious stimuli. We investigated the clinical implication of measuring SAA in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV). Seventy-five patients who had been classified as AAV and enrolled in our prospective observational cohort for AAV patients were included. Clinical and laboratory data were obtained on the day of blood sampling, and SAA was measured by ELISA kits. Birmingham Vasculitis Activity Score (BVAS) and Short-Form 36-Item Health Survey (SF-36) were assessed for disease activity and health-related quality-of-life (HRQoL) measures. We stratified patients into having high BVAS when the BVAS was over the median values, and those with either low SF-36 PCS or low SF-36 MCS were defined as having poor HRQoL. Multivariate logistic regression analysis was conducted to estimate independent predictors of high BVAS. The relative risk (RR) was analyzed using the contingency tables and the chi-squared test. SAA was positively correlated with BVAS (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>r<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.642<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and FFS (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>r<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.367<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) and was inversely correlated with both the SF-36 physical component summary (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>r<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mo>\u2212<\/e:mo>\n                        <e:mn>0.456<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and mental component summary scores (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>r<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mo>\u2212<\/g:mo>\n                        <g:mn>0.394<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Furthermore, SAA was significantly correlated with acute phase reactants ESR (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>r<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.611<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>) and CRP (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>r<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.629<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Patients with high BVAS exhibited significantly higher SAA than those with low BVAS (1317.1\u2009ng\/mL vs. 423.1\u2009ng\/mL). In multivariable logistic regression analysis, serum albumin (odds ratio (OR) 0.132) and <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mtext>SAA<\/m:mtext>\n                        <m:mo>&gt;<\/m:mo>\n                        <m:mn>1173.6<\/m:mn>\n                        <m:mtext>\u2009<\/m:mtext>\n                        <m:mtext>ng<\/m:mtext>\n                        <m:mo>\/<\/m:mo>\n                        <m:mtext>mL<\/m:mtext>\n                     <\/m:math>\n                  <\/jats:inline-formula> (OR 15.132) were independently associated with high BVAS. The risk of having high BVAS and poor HRQoL in patients with <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mtext>SAA<\/o:mtext>\n                        <o:mo>&gt;<\/o:mo>\n                        <o:mn>1173.6<\/o:mn>\n                        <o:mtext>\u2009<\/o:mtext>\n                        <o:mtext>ng<\/o:mtext>\n                        <o:mo>\/<\/o:mo>\n                        <o:mtext>mL<\/o:mtext>\n                     <\/o:math>\n                  <\/jats:inline-formula> was higher than in those with <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mtext>SAA<\/q:mtext>\n                        <q:mo>\u2264<\/q:mo>\n                        <q:mn>1173.6<\/q:mn>\n                        <q:mtext>\u2009<\/q:mtext>\n                        <q:mtext>ng<\/q:mtext>\n                        <q:mo>\/<\/q:mo>\n                        <q:mtext>mL<\/q:mtext>\n                     <\/q:math>\n                  <\/jats:inline-formula> (RR 3.419 and 1.493). Our results suggest that SAA might be a useful biomarker in assessing disease activity and HRQoL in AAV.<\/jats:p>","DOI":"10.1155\/2020\/8847306","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T14:17:44Z","timestamp":1608128264000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Serum Amyloid A Is a Biomarker of Disease Activity and Health-Related Quality-of-Life in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Taejun","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Medical Science, BK21 Plus Project, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Soo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juyoung","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Jungsik","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Beom","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea"},{"name":"Institute for Immunology and Immunological Diseases, Yonsei 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