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However, due to their high free scattering and positional variability, the identification and classification of enhancers have a higher level of complexity than those of coding genes. In order to solve this problem, many computer studies have been carried out in this field, but there are still some deficiencies in these prediction models. In this paper, we use various feature extraction strategies, dimension reduction technology, and a comprehensive application of machine model and recurrent neural network model to achieve an accurate prediction of enhancer identification and classification with the accuracy of was 76.7% and 84.9%, respectively. The model proposed in this paper is superior to the previous methods in performance index or feature dimension, which provides inspiration for the prediction of enhancers by computer technology in the future.<\/jats:p>","DOI":"10.1155\/2020\/8852258","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:05:05Z","timestamp":1603152305000},"page":"1-9","source":"Crossref","is-referenced-by-count":17,"title":["Identification and Classification of Enhancers Using Dimension Reduction Technique and Recurrent Neural Network"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5850-0927","authenticated-orcid":true,"given":"Qingwen","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin, China"},{"name":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-6881","authenticated-orcid":true,"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Electronic and Communication Engineering, Shenzhen Polytechnic, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8579-3390","authenticated-orcid":true,"given":"Qingyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Forestry and Fruit Tree Research Institute, Wuhan Academy of Agricultural Sciences, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-2879","authenticated-orcid":true,"given":"Lichao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Intelligent Manufacturing and Equipment, Shenzhen Institute of Information Technology, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1076"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx449"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00681"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2174\/1574893613666180726163429"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv604"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/srep38741"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty458"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA118.001169"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-6336-3"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00490"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa258"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz779"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00892"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.2174\/156652322001200604150041"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz740"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061773"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx870"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz981"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.00008"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx165"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa144"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2017.09"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5652041"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts565"},{"issue":"1","key":"25","first-page":"1","article-title":"Sequence clustering in bioinformatics: an empirical study","volume":"21","author":"Q. 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