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Many studies were interested in searching for new natural compounds with protective effects on behavioral\u2010like disorders by focusing on oxidative stress as the main causal factor. Here, we assess the potential effect of cell\u2010free extracts from halophilic bacteria on memory, anxiety, and depression\u2010related behaviors in mice, as well as on cognitive deficits, negative symptoms, and some oxidative stress biomarkers in methionine\u2010induced mice models of schizophrenia. Firstly, crude extracts of bacteria isolated from the Dead Sea were screened for their effects on memory and anxiety\u2010 and depression\u2010like behaviors through Y\u2010maze, elevated plus maze, and forced swimming test, respectively, using two doses 60\u2009mg\/kg and 120\u2009mg\/kg. Then, 120\u2009mg\/kg of two bacterial crude extracts, from two strains designated SL<jats:sub>22<\/jats:sub> and BM<jats:sub>20<\/jats:sub> and identified as <jats:italic>Bacillus stratosphericus<\/jats:italic> and <jats:italic>Pseudomonas zhaodongensis<\/jats:italic>, respectively, with significant contents of phenolic and flavonoid\u2010like compounds, were selected for the assessment of cognitive and negative symptom improvement, as well as for their effects on oxidative stress status in methionine\u2010induced mice models of schizophrenia using six groups (controls, methionine, crude extracts solely, and combinations of crude extracts and methionine). Results showed that the administration of the crude extracts caused a significant increase in the spontaneous alternations in the Y\u2010maze task, the time spent in open arms of the elevated plus maze, and a decrease in immobility time in the forced swimming test in comparison with the control group. Furthermore, the administration of bacterial extracts seemed to diminish disorders related to cognitive and negative symptoms of schizophrenia and to improve the oxidative state in the temporal lobes, in comparison with the methionine group. Our findings suggest substantial antioxidant and anti\u2010neuropsychiatric effects of the crude extracts prepared from <jats:italic>Pseudomonas zhaodongensis strain<\/jats:italic> BM<jats:sub>20<\/jats:sub> and <jats:italic>Bacillus stratosphericus strain<\/jats:italic> SL<jats:sub>22<\/jats:sub> and that further studies are needed to purify and to determine the active fraction from the extracts.<\/jats:p>","DOI":"10.1155\/2020\/8852418","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T02:23:34Z","timestamp":1606271014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective Effects of Two Halophilic Crude Extracts from <i>Pseudomonas zhaodongensis<\/i> and <i>Bacillus stratosphericus<\/i> against Memory Deficits and Anxiety\u2010 and Depression\u2010Like Behaviors in Methionine\u2010Induced Schizophrenia in Mice Focusing on Oxidative Stress 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