{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:27:20Z","timestamp":1790252840110,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["2015"],"award-info":[{"award-number":["2015"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["201904010381"],"award-info":[{"award-number":["201904010381"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["RC2015-001"],"award-info":[{"award-number":["RC2015-001"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["pdjh2019b0690"],"award-info":[{"award-number":["pdjh2019b0690"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["2018GkQNCX033"],"award-info":[{"award-number":["2018GkQNCX033"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["2017GKTSCX005"],"award-info":[{"award-number":["2017GKTSCX005"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["2015"],"award-info":[{"award-number":["2015"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["201904010381"],"award-info":[{"award-number":["201904010381"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["RC2015-001"],"award-info":[{"award-number":["RC2015-001"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["pdjh2019b0690"],"award-info":[{"award-number":["pdjh2019b0690"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["2018GkQNCX033"],"award-info":[{"award-number":["2018GkQNCX033"]}]},{"name":"Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme","award":["2017GKTSCX005"],"award-info":[{"award-number":["2017GKTSCX005"]}]},{"name":"Guangzhou Science and Technology Program","award":["2015"],"award-info":[{"award-number":["2015"]}]},{"name":"Guangzhou Science and Technology Program","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"Guangzhou Science and Technology Program","award":["201904010381"],"award-info":[{"award-number":["201904010381"]}]},{"name":"Guangzhou Science and Technology Program","award":["RC2015-001"],"award-info":[{"award-number":["RC2015-001"]}]},{"name":"Guangzhou Science and Technology Program","award":["pdjh2019b0690"],"award-info":[{"award-number":["pdjh2019b0690"]}]},{"name":"Guangzhou Science and Technology Program","award":["2018GkQNCX033"],"award-info":[{"award-number":["2018GkQNCX033"]}]},{"name":"Guangzhou Science and Technology Program","award":["2017GKTSCX005"],"award-info":[{"award-number":["2017GKTSCX005"]}]},{"name":"Pearl River Scholar Foundation of Guangdong Industry Polytechnic","award":["2015"],"award-info":[{"award-number":["2015"]}]},{"name":"Pearl River Scholar Foundation of Guangdong Industry Polytechnic","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"Pearl River Scholar Foundation of Guangdong Industry Polytechnic","award":["201904010381"],"award-info":[{"award-number":["201904010381"]}]},{"name":"Pearl River Scholar Foundation of Guangdong Industry Polytechnic","award":["RC2015-001"],"award-info":[{"award-number":["RC2015-001"]}]},{"name":"Pearl River Scholar Foundation of Guangdong Industry Polytechnic","award":["pdjh2019b0690"],"award-info":[{"award-number":["pdjh2019b0690"]}]},{"name":"Pearl River Scholar Foundation of Guangdong Industry Polytechnic","award":["2018GkQNCX033"],"award-info":[{"award-number":["2018GkQNCX033"]}]},{"name":"Pearl River Scholar Foundation of Guangdong Industry Polytechnic","award":["2017GKTSCX005"],"award-info":[{"award-number":["2017GKTSCX005"]}]},{"name":"Scientific and Technological Innovation Project of College Students in Guangdong Province","award":["2015"],"award-info":[{"award-number":["2015"]}]},{"name":"Scientific and Technological Innovation Project of College Students in Guangdong Province","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"Scientific and Technological Innovation Project of College Students in Guangdong Province","award":["201904010381"],"award-info":[{"award-number":["201904010381"]}]},{"name":"Scientific and Technological Innovation Project of College Students in Guangdong Province","award":["RC2015-001"],"award-info":[{"award-number":["RC2015-001"]}]},{"name":"Scientific and Technological Innovation Project of College Students in Guangdong Province","award":["pdjh2019b0690"],"award-info":[{"award-number":["pdjh2019b0690"]}]},{"name":"Scientific and Technological Innovation Project of College Students in Guangdong Province","award":["2018GkQNCX033"],"award-info":[{"award-number":["2018GkQNCX033"]}]},{"name":"Scientific and Technological Innovation Project of College Students in Guangdong Province","award":["2017GKTSCX005"],"award-info":[{"award-number":["2017GKTSCX005"]}]},{"name":"Youth Innovation Talent Project of Guangdong Province","award":["2015"],"award-info":[{"award-number":["2015"]}]},{"name":"Youth Innovation Talent Project of Guangdong Province","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"Youth Innovation Talent Project of Guangdong Province","award":["201904010381"],"award-info":[{"award-number":["201904010381"]}]},{"name":"Youth Innovation Talent Project of Guangdong Province","award":["RC2015-001"],"award-info":[{"award-number":["RC2015-001"]}]},{"name":"Youth Innovation Talent Project of Guangdong Province","award":["pdjh2019b0690"],"award-info":[{"award-number":["pdjh2019b0690"]}]},{"name":"Youth Innovation Talent Project of Guangdong Province","award":["2018GkQNCX033"],"award-info":[{"award-number":["2018GkQNCX033"]}]},{"name":"Youth Innovation Talent Project of Guangdong Province","award":["2017GKTSCX005"],"award-info":[{"award-number":["2017GKTSCX005"]}]},{"name":"Characteristic Innovation Project of Guangdong Province","award":["2015"],"award-info":[{"award-number":["2015"]}]},{"name":"Characteristic Innovation Project of Guangdong Province","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"Characteristic Innovation Project of Guangdong Province","award":["201904010381"],"award-info":[{"award-number":["201904010381"]}]},{"name":"Characteristic Innovation Project of Guangdong Province","award":["RC2015-001"],"award-info":[{"award-number":["RC2015-001"]}]},{"name":"Characteristic Innovation Project of Guangdong Province","award":["pdjh2019b0690"],"award-info":[{"award-number":["pdjh2019b0690"]}]},{"name":"Characteristic Innovation Project of Guangdong Province","award":["2018GkQNCX033"],"award-info":[{"award-number":["2018GkQNCX033"]}]},{"name":"Characteristic Innovation Project of Guangdong Province","award":["2017GKTSCX005"],"award-info":[{"award-number":["2017GKTSCX005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioinorganic Chemistry and Applications"],"published-print":{"date-parts":[[2020,9,15]]},"abstract":"<jats:p>Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between <jats:italic>\u03b1<\/jats:italic>-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in a monoclinic system. The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.<\/jats:p>","DOI":"10.1155\/2020\/8852470","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T23:35:46Z","timestamp":1600212946000},"page":"1-9","source":"Crossref","is-referenced-by-count":14,"title":["Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives"],"prefix":"10.1155","volume":"2020","author":[{"given":"Zou","family":"Xun-Zhong","sequence":"first","affiliation":[{"name":"Guangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"An-Sheng","sequence":"additional","affiliation":[{"name":"Guangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, China"},{"name":"College of Light Industry and Food, Zhongkai University of Agriculture and Engineering, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"Fu-Ran","sequence":"additional","affiliation":[{"name":"Guangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Min-Cheng","sequence":"additional","affiliation":[{"name":"Guangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liao","family":"Yan-Zhi","sequence":"additional","affiliation":[{"name":"Guangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5414-3432","authenticated-orcid":true,"given":"Mei","family":"Meng","sequence":"additional","affiliation":[{"name":"Wuhan Children\u2019s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430015, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3390-8616","authenticated-orcid":true,"given":"Li","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangdong Research Center for Special Functional Building Materials and Its Green Preparation Technology, Foshan Research Center for Special Functional Building Materials and Its Green Preparation Technology, Guangdong Industry Polytechnic, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"1179","volume":"57","year":"2018","journal-title":"Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.3870"},{"key":"3","first-page":"42","volume":"10","year":"2018","journal-title":"Pharmaceutical Chemistry"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.05.013"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2174\/1573408011666150615211747"},{"key":"6","first-page":"1","volume":"8","year":"2019","journal-title":"Research & Reviews, Journal of Chemistry"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2020.119707"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2019.120906"},{"issue":"17","key":"9","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1021\/acs.organomet.0c00381","volume":"39","year":"2020","journal-title":"Organometallics"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-019-00256-5"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201900545"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.4680"},{"key":"13","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1039\/C6DT04785H","volume":"46","year":"2017","journal-title":"Dalton Transactions"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s10967-011-1404-4"},{"key":"15","volume":"a1","year":"2009","journal-title":"PCT International Application"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1107\/s0021889808042726"},{"key":"17","year":"1997"},{"key":"18","first-page":"112","volume":"64","year":"2008","journal-title":"Acta Crystallographica Section A. Crystal Physics, Diffraction, Theoretical and General Crystallography"},{"key":"19","year":"1999"},{"key":"20","first-page":"29","volume":"3","year":"2014","journal-title":"Weishengwu Qianyan"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1177\/1087057107304478"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2141"},{"key":"23","first-page":"673","volume":"39","year":"2020","journal-title":"Chinese Journal of Structural Chemistry"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03689-8"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/cber.19971300907"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/890734"},{"key":"27","first-page":"910","volume":"55","year":"1964","journal-title":"Phytopathology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/126023"}],"container-title":["Bioinorganic Chemistry and Applications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bca\/2020\/8852470.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bca\/2020\/8852470.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bca\/2020\/8852470.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T23:36:03Z","timestamp":1600212963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/bca\/2020\/8852470\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,15]]},"references-count":28,"alternative-id":["8852470","8852470"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8852470","relation":{},"ISSN":["1565-3633","1687-479X"],"issn-type":[{"value":"1565-3633","type":"print"},{"value":"1687-479X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,15]]}}}