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But no perfect segmentation solution has been found yet. This work is to develop an automatic hand radiograph segmentation method with high precision and efficiency. We considered the hand segmentation task as a classification problem. The optimal segmentation threshold for each image was regarded as the prediction target. We utilized the normalized histogram, mean value, and variance of each image as input features to train the classification model, based on ensemble learning with multiple classifiers. 600 left-hand radiographs with the bone age ranging from 1 to 18 years old were included in the dataset. Compared with traditional segmentation methods and the state-of-the-art U-Net network, the proposed method performed better with a higher precision and less computational load, achieving an average PSNR of 52.43\u2009dB, SSIM of 0.97, DSC of 0.97, and JSI of 0.91, which is more suitable in clinical application. Furthermore, the experimental results also verified that hand radiograph segmentation could bring an average improvement for BAA performance of at least 13%.<\/jats:p>","DOI":"10.1155\/2020\/8866700","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T02:35:14Z","timestamp":1603852514000},"page":"1-12","source":"Crossref","is-referenced-by-count":2,"title":["Ensemble Learning with Multiclassifiers on Pediatric Hand Radiograph Segmentation for Bone Age Assessment"],"prefix":"10.1155","volume":"2020","author":[{"given":"Rui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, Chongqing Medical University, Chongqing 401331, China"},{"name":"Chengdu Second People\u2019s Hospital, Chengdu 610017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5155-2185","authenticated-orcid":true,"given":"Yuanyuan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Chongqing Medical University, Chongqing 401331, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangqian","family":"He","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Chongqing Medical University, Chongqing 401331, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Chongqing Medical University, Chongqing 401331, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhua","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital Affiliated to Chongqing Medical University, Chongqing 400014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Children\u2019s Hospital Affiliated to Chongqing Medical University, Chongqing 400014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Electrical Engineering, University of Electronic Science and Technology, Chengdu 611731, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2016.10.010"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-018-3033-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000786"},{"key":"4","first-page":"282","article-title":"Radiographic atlas of skeletal development of the hand and wrist","volume":"11","author":"S. 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