{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:39:46Z","timestamp":1747190386138,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Neurological Medicine"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>Marchiafava\u2013Bignami disease (MBD) is a rare disorder of unknown etiology, strongly associated with alcoholism and malnutrition. MBD causes primary involvement of the corpus callosum, leading to confusion, dysarthria, seizures, and frequent death. We report the case of a 54-year-old male without a history of alcoholism or known malabsorption disease, who presented with altered consciousness and neurologic impairment. Complex B deficiency was addressed. Magnetic resonance imaging (MRI) showed typical corpus callosum lesions. The clinical features and radiologic images suggested spinal cord involvement. Brain histopathologic findings were consistent with MBD. Despite vitamin replacement therapy, he had a poor outcome.<\/jats:p>","DOI":"10.1155\/2020\/8867383","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T20:20:07Z","timestamp":1603916407000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Marchiafava\u2013Bignami Disease Associated with Spinal Involvement"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8531-8119","authenticated-orcid":true,"given":"Jhon","family":"Perea","sequence":"first","affiliation":[{"name":"Department of Neurology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-7590","authenticated-orcid":true,"given":"Mar\u00eda Bel\u00e9n","family":"Luis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4031-1594","authenticated-orcid":true,"given":"Luciana Grimanesa","family":"L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2712-8704","authenticated-orcid":true,"given":"Sergio","family":"Scollo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-6093","authenticated-orcid":true,"given":"Agustina","family":"Tamargo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0038-7893","authenticated-orcid":true,"given":"Jos\u00e9","family":"Crespo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6679-1069","authenticated-orcid":true,"given":"Maira","family":"Avalle","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2395-992X","authenticated-orcid":true,"given":"Horacio","family":"Solarz","sequence":"additional","affiliation":[{"name":"Anatomical Pathology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4519-2045","authenticated-orcid":true,"given":"Nora","family":"Fern\u00e1ndez Liguori","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9955-8343","authenticated-orcid":true,"given":"Ricardo","family":"Alonso","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanatorio G\u00fcemes\u2014University Hospital, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"68","article-title":"Marchiafava-Bignami disease: a rare entity with a poor outcome","volume":"25","author":"P. 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