{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T20:01:27Z","timestamp":1762027287005,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T00:00:00Z","timestamp":1602892800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2020,10,17]]},"abstract":"<jats:p>IgA vasculitis (formerly known as Henoch\u2013Sch\u00f6nlein purpura or anaphylactoid purpura) is a usually benign vasculitis that affects children of school age. The disease is characterized by the tetrad of palpable purpura, arthralgia\/arthritis, abdominal pain, and hematuria. Treatment of IgA vasculitis is mainly supportive, with administration of simple analgesics. Corticosteroids have been shown to reduce and\/or ameliorate the occurrence of abdominal pain which may be severe. We present two children with IgA vasculitis and severe abdominal pain despite corticosteroid administration, who responded promptly to intravenous \u03b3 globulin (IVIg) with complete resolution of their symptoms and review of the relevant medical literature. Given the toxicity and\/or need for long-term administration of other second-line immunosuppressive therapies in corticosteroid-resistant IgA vasculitis, such as rituximab, cyclosporine, cyclophosphamide, azathioprine, or colchicine, we propose that IVIg may be a useful and safe treatment option, although randomized controlled clinical trials are needed in order to clarify its role in the treatment of abdominal pain in IgA vasculitis.<\/jats:p>","DOI":"10.1155\/2020\/8867621","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T17:35:06Z","timestamp":1602956106000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Intravenous \u03b3 Globulin for Intractable Abdominal Pain due to IgA Vasculitis"],"prefix":"10.1155","volume":"2020","author":[{"given":"George","family":"Naifa","sequence":"first","affiliation":[{"name":"Resident in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Totikidis","sequence":"additional","affiliation":[{"name":"NHS Registra in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Alexiadou","sequence":"additional","affiliation":[{"name":"Resident in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Kolona","sequence":"additional","affiliation":[{"name":"Resident in Pediatrics, Department of Pediatrics, University General Hospital of Alexandroupolis, Alexandroupoli, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-9733","authenticated-orcid":true,"given":"Elpis","family":"Mantadakis","sequence":"additional","affiliation":[{"name":"Pediatrics-Pediatric Hematology\/Oncology, Democritus University of Thrace Faculty of Medicine, Alexandroupoli, Thrace, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"Suppl 1","key":"1","first-page":"i94","article-title":"Vasculitis in children","volume":"30","author":"D. 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