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Province","doi-asserted-by":"publisher","award":["2017A030313601"],"award-info":[{"award-number":["2017A030313601"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["81970147"],"award-info":[{"award-number":["81970147"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["81770170"],"award-info":[{"award-number":["81770170"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2020,12,24]]},"abstract":"<jats:p>Background. Infections are an important cause of morbidity and mortality for acute lymphoblastic leukemia (ALL). However, the reports regarding risk factors of induction-related infection are roughly unknown\/limited in adult T-ALL during induction chemotherapy. Methods. We performed a retrospective cohort study for the prevalence and risk predictors of induction-related infection among consecutive T-ALL patients (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>N<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>97<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) enrolled in a PDT-ALL-LBL clinical trial. Of 97 patients with T-ALL enrolled in the trial, 46 were early T-cell precursor (ETP) ALL and 51 were non-ETP ALL. Results. When compared with non-ETP, ETP ALL subtype was characterized with lower neutrophil count (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mn>1.35<\/c:mn>\n                        <c:mo>\u00d7<\/c:mo>\n                        <c:msup>\n                           <c:mrow>\n                              <c:mn>10<\/c:mn>\n                           <\/c:mrow>\n                           <c:mrow>\n                              <c:mn>9<\/c:mn>\n                           <\/c:mrow>\n                        <\/c:msup>\n                     <\/c:math>\n                  <\/jats:inline-formula>\/L vs. <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mn>8.7<\/e:mn>\n                        <e:mo>\u00d7<\/e:mo>\n                        <e:msup>\n                           <e:mrow>\n                              <e:mn>10<\/e:mn>\n                           <\/e:mrow>\n                           <e:mrow>\n                              <e:mn>9<\/e:mn>\n                           <\/e:mrow>\n                        <\/e:msup>\n                     <\/e:math>\n                  <\/jats:inline-formula>\/L, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>) and lower myeloid percentage in the bone marrow (13.35% vs. 35.31%, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.007<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Additionally, ETP ALL had longer neutropenia before diagnosis (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.001<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>), as well as during induction chemotherapy (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.001<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>). Notably, the ETP cohort experienced higher cumulative incidence of clinically documented infections (CDI; 33.33%, <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>P<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.001<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>), microbiologically documented infections (MDI; 45.24%, <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>P<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.006<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>), resistant infection (11.9%, <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>P<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.013<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>), and mixed infection (21.43%, <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>P<\/u:mi>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>0.003<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>), respectively, than those of the non-ETP cohort. Furthermore, multivariable analysis revealed that T-ALL mixed infection was more likely related to chemotherapy response (OR, 0.025; 95% CI 0.127-0.64; <jats:inline-formula>\n                     <w:math xmlns:w=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\">\n                        <w:mi>P<\/w:mi>\n                        <w:mo>=<\/w:mo>\n                        <w:mn>0.012<\/w:mn>\n                     <\/w:math>\n                  <\/jats:inline-formula>) and identified myeloid percentage as a predictor associated with ETP-ALL mixed infection (OR, 0.915; 95% CI 0.843-0.993; <jats:inline-formula>\n                     <y:math xmlns:y=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\">\n                        <y:mi>P<\/y:mi>\n                        <y:mo>=<\/y:mo>\n                        <y:mn>0.033<\/y:mn>\n                     <\/y:math>\n                  <\/jats:inline-formula>), with ROC-defined cut-off value of 2.24% in ETP cohorts. Conclusions. Our data for the first time demonstrated that ETP-ALL characterized with impaired myelopoiesis were more susceptible to induction-related infection among T-ALL populations.<\/jats:p>","DOI":"10.1155\/2020\/8867760","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T18:20:49Z","timestamp":1608834049000},"page":"1-10","source":"Crossref","is-referenced-by-count":11,"title":["Early T-Cell Precursor Leukemia Has a Higher Risk of Induction-Related Infection among T-Cell Acute Lymphoblastic Leukemia in Adult"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7357-357X","authenticated-orcid":true,"given":"Kangyu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology, Nanfang Hospital, Southern Medical University, Rd 1838 North Guangzhou Avenue, Guangzhou 510515, 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