{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:20:40Z","timestamp":1783790440595,"version":"3.55.0"},"reference-count":93,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Microbiology"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>The \u201cfocal infection theory\u201d is a historical concept based on the assumption that some infections may cause chronic and acute diseases in different districts of the body. Its great popularity spanned from 1930 to 1950 when, with the aim to remove all the foci of infection, drastic surgical interventions were performed. Periodontitis, a common oral pathology mainly of bacterial origin, is the most evident example of this phenomenon today: in fact, bacteria are able to migrate, develop and cause health problems such as cardiovascular and respiratory diseases, diabetes, and osteoporosis. The aim of this narrative report is to verify the hypothesis of the association between oral infections and systemic diseases by different ways of approach and, at the same time, to propose new kinds of treatment today made possible by technological progress. The analysis of the literature demonstrated a strong relationship between these conditions, which might be explained on the basis of the recent studies on microbiota movement inside the body. Prevention of the oral infections, as well as of the possible systemic implications, may be successfully performed with the help of new technologies, such as probiotics and laser.<\/jats:p>","DOI":"10.1155\/2020\/8875612","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T18:08:32Z","timestamp":1603994912000},"page":"1-9","source":"Crossref","is-referenced-by-count":17,"title":["Focal Infection and Periodontitis: A Narrative Report and New Possible Approaches"],"prefix":"10.1155","volume":"2020","author":[{"given":"Jean-Paul","family":"Rocca","sequence":"first","affiliation":[{"name":"Shijiazhuang 2nd Hospital, Department of Stomatology (South), Gonguong Road 425, Quoxi District, Shijiazhuang, China"},{"name":"UFRO dontologie, UPR Micoralis, University C\u00f4te d\u2019Azur, 24 Avenue des Diables Bleus, 06354 Nice Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7566-060X","authenticated-orcid":true,"given":"Carlo","family":"Fornaini","sequence":"additional","affiliation":[{"name":"Shijiazhuang 2nd Hospital, Department of Stomatology (South), Gonguong Road 425, Quoxi District, Shijiazhuang, China"},{"name":"UFRO dontologie, UPR Micoralis, University C\u00f4te d\u2019Azur, 24 Avenue des Diables Bleus, 06354 Nice Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuomin","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Chaoyang Hospital, Department of Stomatology, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Tan","sequence":"additional","affiliation":[{"name":"Shijiazhuang 2nd Hospital, Department of Diabetes, Gonguong Road 425, Quoxi District, Shijiazhuang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Merigo","sequence":"additional","affiliation":[{"name":"Shijiazhuang 2nd Hospital, Department of Stomatology (South), Gonguong Road 425, Quoxi District, Shijiazhuang, China"},{"name":"UFRO dontologie, UPR Micoralis, University C\u00f4te d\u2019Azur, 24 Avenue des Diables Bleus, 06354 Nice Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1159\/000324620"},{"key":"2","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781139855952","volume-title":"Clinical Infectious Disease","author":"D. 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