{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:40:25Z","timestamp":1747190425975,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Neurological Medicine"],"published-print":{"date-parts":[[2020,10,29]]},"abstract":"<jats:p>We describe an unusual cause of cranial dural thickening in an elderly female with a chronic meningeal inflammatory process. A 70-year-old ethnically Chinese, Singaporean female presented with a history of chronic daily headache with no other meningeal signs. Serial MRI brains showed progressive pachymeningeal and leptomeningeal enhancement in the left frontal region with underlying vasogenic oedema, similar appearances in the right frontal region to a lesser extent, and persistent inflammatory changes in her bilateral paranasal sinuses. Investigative work-up showed a chronically raised ESR with a normal CRP, negative ANCA, and a chronically raised serum IgA kappa paraprotein. Bone marrow trephine biopsy was suggestive of a low level plasma cell disorder. Olfactory cleft biopsy showed no evidence of IgG4-related disease or vasculitis and no significant plasma cell infiltrate. Histopathological examination from a meningeal biopsy revealed a diagnosis of an en-plaque meningioma (the WHO, 2016; Grade I) causing an unusual granulomatous reaction. We discuss the radiological and histological relations of this rare form of meningioma. Clinicians can consider en-plaque meningioma in the differential diagnosis of linear dural thickening and enhancement.<\/jats:p>","DOI":"10.1155\/2020\/8877738","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T19:35:08Z","timestamp":1604000108000},"page":"1-4","source":"Crossref","is-referenced-by-count":1,"title":["An Unusual Cause of Cranial Dural Thickening"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-1699","authenticated-orcid":true,"given":"Jing Ming","family":"Yeo","sequence":"first","affiliation":[{"name":"Department of Neurology, Queen\u2019s Medical Centre, Nottingham University Hospitals NHS Trust, Derby Road, Lenton, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4105-1846","authenticated-orcid":true,"given":"Donald","family":"MacArthur","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-4149","authenticated-orcid":true,"given":"Jillian","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1266-9521","authenticated-orcid":true,"given":"Ian","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6384-2342","authenticated-orcid":true,"given":"Bruno","family":"Gran","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"1","key":"1","first-page":"119","article-title":"Idiopathic hypertrophic cranial pachymeningitis: case report with 7 years of imaging follow-up","volume":"24","author":"Y. 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