{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:38:01Z","timestamp":1747190281890,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2020,11,23]]},"abstract":"<jats:p>Background. A novel coronavirus identified in 2019 leads to a pandemic of severe acute respiratory distress syndrome with important morbidity and mortality. Initially, children seemed minimally affected, but there were reports of cases similar to (atypical) Kawasaki disease or toxic shock syndrome, and evidence emerges about a complication named paediatric inflammatory multisystem syndrome temporarily associated with SARS-CoV-2 (PIMS-TS) or multisystem inflammatory syndrome in children (MIS-C). Case Presentations. Two cases were compared and discussed demonstrating varying presentations, management, and evolution of MIS-C. These cases are presented to increase awareness and familiarity among paediatricians and emergency physicians with the different clinical manifestations of this syndrome. Discussion. MIS-C may occur with possible diverse clinical presentations. Early recognition and treatment are paramount for a beneficial outcome.<\/jats:p>","DOI":"10.1155\/2020\/8878946","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T02:10:22Z","timestamp":1606270222000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Varying Presentations of Multisystem Inflammatory Syndrome Temporarily Associated with COVID-19"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9624-9948","authenticated-orcid":true,"given":"Jasmina","family":"Krikilion","sequence":"first","affiliation":[{"name":"Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Paediatrics, Brussel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-2249","authenticated-orcid":true,"given":"Lisa","family":"Nuyttens","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Paediatrics, Brussel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6056-8533","authenticated-orcid":true,"given":"Siel","family":"Daelemans","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Paediatrics, Brussel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0071-8402","authenticated-orcid":true,"given":"Karlien","family":"Fran\u00e7ois","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Division of Nephrology and Hypertension, Brussel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-1230","authenticated-orcid":true,"given":"Reiner","family":"Mauel","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Paediatrics, Brussel, Belgium"},{"name":"Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Paediatric Emergency and Intensive Care Unit, Brussel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-2817","authenticated-orcid":true,"given":"Daniel","family":"De Wolf","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Paediatrics, Brussel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3674-9083","authenticated-orcid":true,"given":"Gerlant","family":"van Berlaer","sequence":"additional","affiliation":[{"name":"Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Paediatric Emergency and Intensive Care Unit, Brussel, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"volume-title":"Coronavirus","year":"2020","author":"World Health Organization","key":"1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2007617"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)31094-1"},{"volume-title":"Guidance: Paediatric Multisystem Inflammatory Syndrome Temporally Associated with COVID-19","year":"2020","author":"Royal College of Paediatrics and Child Health","key":"4"},{"volume-title":"Multisystem Inflammatory Syndrome in Children and Adolescents Temporally Related to COVID-19 [Scientific Brief]","year":"2020","author":"World Health Organization","key":"5"},{"volume-title":"Information for Healthcare Providers about Multisystem Inflammatory Syndrome in Children (MIS-C)","year":"2020","author":"Center for Disease Control and Prevention (CDC)","key":"6"},{"volume-title":"Multisystem Inflammatory Syndrome in Children and Adolescents with COVID-19","year":"2020","author":"World Health Organization (WHO)","key":"7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-1711"},{"issue":"7","key":"9","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102568","article-title":"Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: a single center study of 100 patients in brescia, Italy","volume":"19","author":"P. 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