{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:51:39Z","timestamp":1782345099840,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joint Sino-German Research Project","award":["GZ1236"],"award-info":[{"award-number":["GZ1236"]}]},{"name":"Joint Sino-German Research Project","award":["Z161100002616003"],"award-info":[{"award-number":["Z161100002616003"]}]},{"name":"Joint Sino-German Research Project","award":["PRRD-2016-ZD2"],"award-info":[{"award-number":["PRRD-2016-ZD2"]}]},{"name":"Joint Sino-German Research Project","award":["A1-AFD018181Z3905"],"award-info":[{"award-number":["A1-AFD018181Z3905"]}]},{"name":"Joint Sino-German Research Project","award":["GH2017-07"],"award-info":[{"award-number":["GH2017-07"]}]},{"name":"Joint Sino-German Research Project","award":["2018YFC1705800"],"award-info":[{"award-number":["2018YFC1705800"]}]},{"name":"Fundamental Research Funds for Beijing Municipal Science & Technology Commission","award":["GZ1236"],"award-info":[{"award-number":["GZ1236"]}]},{"name":"Fundamental Research Funds for Beijing Municipal Science & Technology Commission","award":["Z161100002616003"],"award-info":[{"award-number":["Z161100002616003"]}]},{"name":"Fundamental Research Funds for Beijing Municipal Science & Technology Commission","award":["PRRD-2016-ZD2"],"award-info":[{"award-number":["PRRD-2016-ZD2"]}]},{"name":"Fundamental Research Funds for Beijing Municipal Science & Technology Commission","award":["A1-AFD018181Z3905"],"award-info":[{"award-number":["A1-AFD018181Z3905"]}]},{"name":"Fundamental Research Funds for Beijing Municipal Science & Technology Commission","award":["GH2017-07"],"award-info":[{"award-number":["GH2017-07"]}]},{"name":"Fundamental Research Funds for Beijing Municipal Science & Technology Commission","award":["2018YFC1705800"],"award-info":[{"award-number":["2018YFC1705800"]}]},{"DOI":"10.13039\/501100014957","name":"Beijing Key Laboratory of Plant Resources Research and Development","doi-asserted-by":"publisher","award":["GZ1236"],"award-info":[{"award-number":["GZ1236"]}],"id":[{"id":"10.13039\/501100014957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014957","name":"Beijing Key Laboratory of Plant Resources Research and Development","doi-asserted-by":"publisher","award":["Z161100002616003"],"award-info":[{"award-number":["Z161100002616003"]}],"id":[{"id":"10.13039\/501100014957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014957","name":"Beijing Key Laboratory of Plant Resources Research and Development","doi-asserted-by":"publisher","award":["PRRD-2016-ZD2"],"award-info":[{"award-number":["PRRD-2016-ZD2"]}],"id":[{"id":"10.13039\/501100014957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014957","name":"Beijing Key Laboratory of Plant Resources Research and Development","doi-asserted-by":"publisher","award":["A1-AFD018181Z3905"],"award-info":[{"award-number":["A1-AFD018181Z3905"]}],"id":[{"id":"10.13039\/501100014957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014957","name":"Beijing Key Laboratory of Plant Resources Research and Development","doi-asserted-by":"publisher","award":["GH2017-07"],"award-info":[{"award-number":["GH2017-07"]}],"id":[{"id":"10.13039\/501100014957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014957","name":"Beijing Key Laboratory of Plant Resources Research and Development","doi-asserted-by":"publisher","award":["2018YFC1705800"],"award-info":[{"award-number":["2018YFC1705800"]}],"id":[{"id":"10.13039\/501100014957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013137","name":"Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme","doi-asserted-by":"publisher","award":["GZ1236"],"award-info":[{"award-number":["GZ1236"]}],"id":[{"id":"10.13039\/501100013137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013137","name":"Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme","doi-asserted-by":"publisher","award":["Z161100002616003"],"award-info":[{"award-number":["Z161100002616003"]}],"id":[{"id":"10.13039\/501100013137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013137","name":"Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme","doi-asserted-by":"publisher","award":["PRRD-2016-ZD2"],"award-info":[{"award-number":["PRRD-2016-ZD2"]}],"id":[{"id":"10.13039\/501100013137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013137","name":"Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme","doi-asserted-by":"publisher","award":["A1-AFD018181Z3905"],"award-info":[{"award-number":["A1-AFD018181Z3905"]}],"id":[{"id":"10.13039\/501100013137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013137","name":"Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme","doi-asserted-by":"publisher","award":["GH2017-07"],"award-info":[{"award-number":["GH2017-07"]}],"id":[{"id":"10.13039\/501100013137","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013137","name":"Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme","doi-asserted-by":"publisher","award":["2018YFC1705800"],"award-info":[{"award-number":["2018YFC1705800"]}],"id":[{"id":"10.13039\/501100013137","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Cooperation Project of Traditional Chinese Medicine in China Academy of Chinese Medical Sciences","award":["GZ1236"],"award-info":[{"award-number":["GZ1236"]}]},{"name":"International Cooperation Project of Traditional Chinese Medicine in China Academy of Chinese Medical Sciences","award":["Z161100002616003"],"award-info":[{"award-number":["Z161100002616003"]}]},{"name":"International Cooperation Project of Traditional Chinese Medicine in China Academy of Chinese Medical Sciences","award":["PRRD-2016-ZD2"],"award-info":[{"award-number":["PRRD-2016-ZD2"]}]},{"name":"International Cooperation Project of Traditional Chinese Medicine in China Academy of Chinese Medical Sciences","award":["A1-AFD018181Z3905"],"award-info":[{"award-number":["A1-AFD018181Z3905"]}]},{"name":"International Cooperation Project of Traditional Chinese Medicine in China Academy of Chinese Medical Sciences","award":["GH2017-07"],"award-info":[{"award-number":["GH2017-07"]}]},{"name":"International Cooperation Project of Traditional Chinese Medicine in China Academy of Chinese Medical Sciences","award":["2018YFC1705800"],"award-info":[{"award-number":["2018YFC1705800"]}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["GZ1236"],"award-info":[{"award-number":["GZ1236"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["Z161100002616003"],"award-info":[{"award-number":["Z161100002616003"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["PRRD-2016-ZD2"],"award-info":[{"award-number":["PRRD-2016-ZD2"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["A1-AFD018181Z3905"],"award-info":[{"award-number":["A1-AFD018181Z3905"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["GH2017-07"],"award-info":[{"award-number":["GH2017-07"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2018YFC1705800"],"award-info":[{"award-number":["2018YFC1705800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2020,10,21]]},"abstract":"<jats:p>Depression and pain disorders share a high degree of comorbidity. Inflammatory mechanisms play an important role in the pathogenesis of depression-chronic somatic pain comorbidity. In this study, we investigated the effects of acupuncture on blood and brain regional tumor necrosis factor alpha (TNF-\u03b1) in rats with depression and chronic somatic pain comorbidity. Forty Sprague-Dawley rats were randomly divided into the following 4 groups with 10 each: control, model, model treated with transcutaneous auricular vagus nerve stimulation (taVNS), and model treated with electroacupuncture (EA). Chronic unpredictable mild stress (CUMS) with chronic constriction injury of the sciatic nerve (CCI) was used to produce depression and chronic somatic pain comorbidity in the latter 3 groups. The rats of the taVNS and EA groups received, respectively, taVNS and EA at ST 36 for 28 days. Pain intensity was measured using a mechanical withdrawal threshold and thermal stimulation latency once biweekly. Depressive behavior was examined using a sucrose preference test at baseline and the end of modeling and intervention. The level of plasma TNF-\u03b1 and the expression of TNF-\u03b1 in the prefrontal cortex (PFC), hippocampus, amygdala, and hypothalamus were measured. While CUMS plus CCI produced remarkable depression-like behavior and pain disorders, EA and taVNS significantly improved depression and reduced pain intensity. CUMS plus CCI also resulted in a significant increase in plasma TNF-\u03b1 level and the expression in all brain regions examined compared to the intact controls. Both EA and taVNS interventions, however, suppressed the elevated level of TNF-\u03b1. These results suggest that EA and taVNS have antidepressant and analgesic effects. Such effects may be associated with the suppression of TNF-\u03b1-related neuroinflammation.<\/jats:p>","DOI":"10.1155\/2020\/8885729","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T17:20:09Z","timestamp":1603387209000},"page":"1-10","source":"Crossref","is-referenced-by-count":44,"title":["Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Peripheral and Central Tumor Necrosis Factor Alpha in Rats with Depression-Chronic Somatic Pain Comorbidity"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6140-6595","authenticated-orcid":true,"given":"Xiao","family":"Guo","sequence":"first","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"},{"name":"Department of Scientific Research Management, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, First Hospital of Hebei Medical University, Shijiazhuang 050031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"},{"name":"Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jiao","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Meng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cosmetic, China National Light Industry, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8416-3426","authenticated-orcid":true,"given":"Zhangjin","family":"Zhang","sequence":"additional","affiliation":[{"name":"The School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7288-2319","authenticated-orcid":true,"given":"Peijing","family":"Rong","sequence":"additional","affiliation":[{"name":"Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"346","article-title":"Depression and pain: often together but still a clinical challenge: a review","volume":"24","author":"N. Rijavec","year":"2012","journal-title":"Psychiatria Danubina"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/504691"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.09.044"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12448"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182657b3e"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1159\/000435931"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9724371"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.03.039"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666150630171433"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034431"},{"issue":"3","key":"11","first-page":"462","article-title":"Present situation and prospect of transcutaneous auricular vagus nerve stimulation in encephalopathy treatment","volume":"19","author":"Y. T. Yu","year":"2017","journal-title":"Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1590\/0004-282X20140061"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3728752"},{"issue":"2","key":"14","first-page":"47","article-title":"Effect of acupuncture and moxibustion at Baihui and Zusanli on behavior of mouse and rat depression model","volume":"19","author":"H. Sun","year":"2003","journal-title":"Journal of Clinical Acupuncture and Moxibustion"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.13702\/j.1000-0607.170450"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S150028"},{"issue":"4","key":"17","first-page":"555","article-title":"Comparision of the chronic constriction injury of the sciatic nerve (CCI) models performed by different materials in neuropathic pain of rats","volume":"24","author":"C. Ma","year":"2008","journal-title":"Chinese Pharmacological Bulletin"},{"key":"18","volume-title":"The Study of Electroacupuncture Auricular Concha Region Regulating Plasma Melatonin of Zucker Diabetes Fat Rat to Relieve Neuralgia and Hypoglycemia","author":"X. Zhai","year":"2013"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0254-6272(17)30013-4"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2018.01.006"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2017.12.018"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00020"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/732845"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/129875"},{"issue":"3","key":"25","first-page":"195","article-title":"Effect of acupuncture at Baihui (GV 20) and Zusanli (ST 36) on the level of serum inflammatory cytokines in patients with depression","volume":"30","author":"H. Sun","year":"2010","journal-title":"Chinese Acupuncture & Moxibustion"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1124\/pr.113.008144"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.04.060"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.907628"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1759-9"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2018.1482179"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6471984"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/787393"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/627023"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v11i2.35"},{"issue":"4","key":"35","first-page":"295","article-title":"Establishment and explanation of the theory of \u2018enlightening the Spirit by modulating pivot\u2019 on depression treatment","volume":"60","author":"P. J. Rong","year":"2019","journal-title":"Journal of Traditional Chinese Medicine"},{"issue":"16","key":"36","first-page":"2890","article-title":"Study on relationship between substance P and its receptor Neurokinin-1 receptor with pain","volume":"21","author":"G. M. Zhao","year":"2015","journal-title":"Medical Recapitulate"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601751"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00296"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2293-z"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071596"},{"issue":"7","key":"41","first-page":"80","article-title":"Advances in roles of substance P and substance P receptor in neuropathic pain","volume":"53","author":"M. Yang","year":"2013","journal-title":"Journal of Nanchang University"}],"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2020\/8885729.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2020\/8885729.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2020\/8885729.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T17:20:33Z","timestamp":1603387233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/np\/2020\/8885729\/"}},"subtitle":[],"editor":[{"given":"Yongjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,21]]},"references-count":41,"alternative-id":["8885729","8885729"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8885729","relation":{},"ISSN":["1687-5443","2090-5904"],"issn-type":[{"value":"1687-5443","type":"electronic"},{"value":"2090-5904","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,21]]}}}