{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:38:49Z","timestamp":1747190329166,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complexity"],"published-print":{"date-parts":[[2020,11,27]]},"abstract":"<jats:p>Robot-assisted retinal cannulation is an eye surgical procedure which can dissolve the obstruction by using robot to inject anticoagulant into occluded vessel. The current research on the critical parameters of cannulation for human is scarce because of the immature technology. Considering the influence of microneedle, this work investigated the effects of drug concentration, injection velocity, injection position, and size of clot on cannulation by theoretical analysis and finite element analysis. For finite element analysis, the multiphysics continuum model was established to demonstrate species transport and reaction which simulates the entire lytic process of the occlusive clot, and four cell zones were established to describe the generation of plasmin (PLS) with the addition of tissue-type plasminogen activator (tPA) and fibrinolysis of clot by importing subroutines into each cell zone under the conditions of constant clot size and variable size, respectively. The results imply that the most efficient value of tPA concentration is 50\u2009nM, injection velocity is 60\u2009mm\/s for clot length of 0.1\u2009mm, and the best position to insert the cannula is 0.5\u2009mm in front of the thrombus. For different clot lengths of 0.1\u2009mm to 0.6\u2009mm, the optimal range of tPA concentration and injection velocity is from 20\u2009nM to 70\u2009nM and from 40\u2009mm\/s to 60\u2009mm\/s, respectively, and explores the reasonable injection position of 0.3\u2009mm to 0.5\u2009mm in front of clot in a vein of 100\u2009\u03bcm. This conclusion can be used to perform robot-assisted cannulation surgery to improve fibrinolytic efficiency.<\/jats:p>","DOI":"10.1155\/2020\/8886039","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T02:50:05Z","timestamp":1606531805000},"page":"1-12","source":"Crossref","is-referenced-by-count":1,"title":["Numerical Simulation of Thrombolysis in Robot-Assisted Retinal Vein Cannulation"],"prefix":"10.1155","volume":"2020","author":[{"given":"Shunlei","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Advanced Manufacturing Technology, Beijing University of Technology, Beijing 100124, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Pan","sequence":"additional","affiliation":[{"name":"Faculty of Information Engineering and Automation, Kunming University of Science and Technology, Kunming 650031, China"},{"name":"College of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4473-8045","authenticated-orcid":true,"given":"Juan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baobao","family":"Qi","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Advanced Manufacturing Technology, Beijing University of Technology, Beijing 100124, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.07.017"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/02713680701851902"},{"issue":"4","key":"3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1001\/archopht.1997.01100150488006","article-title":"Natural history and clinical management of central retinal vein occlusion","volume":"115","author":"J. 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