{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:23:41Z","timestamp":1770837821964,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T00:00:00Z","timestamp":1604707200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Vascular Medicine"],"published-print":{"date-parts":[[2020,11,7]]},"abstract":"<jats:p>Background. Myeloproliferative neoplasms are a heterogeneous group of disorders resulting from the abnormal proliferation of one or more terminal myeloid cells\u2014established complications include thrombosis and haemorrhagic events; however, there is limited evidence to suggest an association with arterial hypertension. Herein, we report two independent cases of severe hypertension in JAK2 mutation-positive myeloproliferative neoplasms. Case Presentations. Case 1: a 39-year-old male was referred to our specialist hypertension unit with high blood pressure (BP) (200\/120\u2009mmHg), erythromelalgia, and headaches. We recorded elevated serum creatinine levels (146\u2009\u03bcM) and panmyelosis. Bone marrow biopsy confirmed JAK2-mutation-positive polycythaemia vera. Renal imaging revealed renal artery stenosis. Aspirin, long-acting nifedipine, interferon-alpha 2A, and renal artery angioplasty were employed in management. BP reached below target levels to an average of 119\/88\u2009mmHg. Renal parameters normalised gradually alongside BP. Case 2: a 45-year-old male presented with high BP (208\/131\u2009mmHg), acrocyanosis, (vasculitic) skin rashes, and nonhealing ulcers. Fundoscopy showed optic disc blurring in the left eye and full blood count revealed thrombocytosis. Bone marrow biopsy confirmed JAK2-mutation-positive essential thrombocytosis. No renal artery stenosis was found. Cardiac output was measured at 5\u2009L\/min using an inert gas rebreathing method, providing an estimated peripheral vascular resistance of 1840 dynes\/s\/cm5. BP was well-controlled (reaching 130\/70\u2009mmHg) with CCBs. Conclusions. These presentations highlight the utility of full blood count analysis in patients with severe hypertension. Hyperviscosity and constitutive JAK-STAT activation are amongst the proposed pathophysiology linking myeloproliferative neoplasms and hypertension. Further experimental and clinical research is necessary to identify and understand possible interactions between BP and myeloproliferative neoplasms.<\/jats:p>","DOI":"10.1155\/2020\/8887423","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:51:22Z","timestamp":1604969482000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Two Cases of Severe Hypertension in JAK2 Mutation-Positive Myeloproliferative Neoplasms"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-575X","authenticated-orcid":true,"given":"Raunak","family":"Rao","sequence":"first","affiliation":[{"name":"Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0598-9834","authenticated-orcid":true,"given":"Spoorthy","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian B.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014594"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5702983"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313512010"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-018-0124-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2018.08.020"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-018-0179-1"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.12.002"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1177\/1076029618766260"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001454"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S27415"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13274"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310753"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/jch.13257"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.4161\/jkst.22729"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2079"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr059"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00071.2011"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00181.2005"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00163.2003"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm509"}],"container-title":["Case Reports in Vascular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crivam\/2020\/8887423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crivam\/2020\/8887423.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crivam\/2020\/8887423.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:51:23Z","timestamp":1604969483000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crivam\/2020\/8887423\/"}},"subtitle":[],"editor":[{"given":"Nilda","family":"Espinola-Zavaleta","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,7]]},"references-count":20,"alternative-id":["8887423","8887423"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8887423","relation":{},"ISSN":["2090-6994","2090-6986"],"issn-type":[{"value":"2090-6994","type":"electronic"},{"value":"2090-6986","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11,7]]}}}