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Many genes associated with AHL have been mapped in a variety of strains. However, little is known about gene variants that have the converse function\u2014protective genes that confer strong resistance to hearing loss. Previously, we reported that C57BL\/6J (B6) and DBA\/2J (D2) strains share a common hearing loss allele in <jats:italic>Cdh23<\/jats:italic>. The cadherin 23 (<jats:italic>Cdh23<\/jats:italic>) gene is a key contributor to early-onset hearing loss in humans. In this study, we tested hearing across a large family of 54 BXD strains generated from B6 to D2 crosses. Five of 54 strains maintain the normal threshold (20\u2009dB SPL) even at 2 years old\u2014an age at which both parental strains are essentially deaf. Further analyses revealed an age-related hearing protection (<jats:italic>ahp<\/jats:italic>) locus on chromosome 16 (Chr 16) at 57~76\u2009Mb with a maximum LOD of 5.7. A small number of BXD strains at 2 years with good hearing correspond roughly to the percentage of humans who have good hearing at 90 years old. Further studies to define candidate genes in the <jats:italic>ahp<\/jats:italic> locus and related molecular mechanisms involved in age-related resilience or resistance to AHL are warranted.<\/jats:p>","DOI":"10.1155\/2020\/8889264","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T23:32:52Z","timestamp":1591659172000},"page":"1-11","source":"Crossref","is-referenced-by-count":7,"title":["An Age-Related Hearing Protection Locus on Chromosome 16 of BXD Strain Mice"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5827-4106","authenticated-orcid":true,"given":"Qing Yin","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University, Cleveland, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Kui","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck 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