{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T22:32:02Z","timestamp":1740177122210,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z151100004015064"],"award-info":[{"award-number":["Z151100004015064"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Gastroenterology and Hepatology"],"published-print":{"date-parts":[[2020,12,21]]},"abstract":"<jats:p>Objective. To investigate the effect of splenectomy for correction of systemic hemodynamic disorders in hepatic cirrhosis patients with portal hypertension. Methods. Hepatic cirrhosis patients with portal hypertension were enrolled from April 2015 to July 2018. Systemic hemodynamic parameters (heart rate, mean arterial pressure (MAP), cardiac output, and total peripheral vascular resistance (TPR)) were prospectively measured at baseline and 1 week, 1, 3, and 6 months, and 1, 2, and 3 years postoperatively. Paired analysis was conducted. Results. Sixty-nine patients were eligible, and 55 (79.7%) cases had a history of upper gastrointestinal bleeding. Child\u2013Pugh classification was grade A in 41 (59.4%) cases, grade B in 26 (37.7%) cases, and grade C in 2 (2.9%) cases. The heart rate was significantly higher at 1 week postoperatively versus the baseline (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Meanwhile, the heart rate was significantly lower from 3 months to 2 years postoperatively versus the baseline (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The MAP was significantly higher at 6 months to 2 years postoperatively versus the baseline (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). At 1 month postoperatively and 6 months to 2 years, the cardiac output was significantly lower versus the baseline (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). At 1 month postoperatively and 6 months to 2 years, the TPR was significantly higher versus the baseline (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Conclusion. Splenectomy corrects systemic hemodynamic disorder in hepatic cirrhosis patients with portal hypertension, and the effect is rapid and durable.<\/jats:p>","DOI":"10.1155\/2020\/8893119","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T01:05:28Z","timestamp":1608599128000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Splenectomy with Portoazygous Disconnection for Correction of Systemic Hemodynamic Disorders in Hepatic Cirrhosis Patients with Portal Hypertension: A Prospective Single-Center Cohort Study"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9675-5659","authenticated-orcid":true,"given":"Dao-Bing","family":"Zeng","sequence":"first","affiliation":[{"name":"General Surgery Department, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Di","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Liang","family":"Guo","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ding","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fei","family":"Zhao","sequence":"additional","affiliation":[{"name":"General Surgery Department, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Chun","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute and Hospital of Hepatobiliary Surgery of Chinese PLA, Chinese PLA Medical School, Chinese PLA General Hospital, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.07.004"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3350\/kjhep.2008.14.2.150"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-15"},{"key":"4","first-page":"211","article-title":"Assessment and current treatment of portal hypertension","volume":"11","author":"S. K. Baik","year":"2005","journal-title":"The Korean Journal of Hepatology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12360"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840170302"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i8.1292"},{"key":"8","first-page":"306","article-title":"Clinical efficacy of devascularization in treatment of esophageal and gastric varices in cirrhosis patients with portal hypertension","volume":"8","author":"D. B. Zeng","year":"2019","journal-title":"Chinese Journal of General Surgery (Electronic Edition)"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9622"},{"key":"10","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.cgh.2015.06.039","article-title":"Covert and overt hepatic encephalopathy: diagnosis and management","volume":"13","author":"K. R. Patidar","year":"201","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"11","first-page":"19","article-title":"Experts group from the ministry of health special funds for Research in the public interest. Expert consensus on technical specification of pericardial devascularization (2013 edition)","volume":"01","author":"Chinese Journal of Digestive Surgery","year":"2014","journal-title":"Chinese Journal of Digestive Surgery"},{"key":"12","first-page":"648","article-title":"Clinical analysis of splenectomy and selective devasculatization based on intra-operative free portal pressure","volume":"9","author":"J. L. Cao","year":"2014","journal-title":"Chinese Journal of Hepatobiliary Surgery"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300112"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1172\/jci102813"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-195707000-00006"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(58)90322-x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1056\/nejm196211222672105"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(64)90066-x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196509000-00005"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.064329"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150214"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2000.020001051.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12195"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095736"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90441-6"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.4321\/s1130-01082008000800007"}],"container-title":["Canadian Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2020\/8893119.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2020\/8893119.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjgh\/2020\/8893119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T01:05:30Z","timestamp":1608599130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cjgh\/2020\/8893119\/"}},"subtitle":[],"editor":[{"given":"Quirino","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,21]]},"references-count":26,"alternative-id":["8893119","8893119"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8893119","relation":{},"ISSN":["2291-2797","2291-2789"],"issn-type":[{"type":"electronic","value":"2291-2797"},{"type":"print","value":"2291-2789"}],"subject":[],"published":{"date-parts":[[2020,12,21]]}}}