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Recent clinical and experimental data indicate that gut microbiota plays a pivotal role in the pathogenesis of UC. <jats:italic>Chlamydia<\/jats:italic> establishes a stable and persistent colonization in the gastrointestinal tract without apparent pathogenicity to gastrointestinal or extragastrointestinal tissues. However, the detailed effects of <jats:italic>Chlamydia<\/jats:italic> on the gastrointestinal tissue remain unknown. The primary aim of this study is to investigate the effects of <jats:italic>Chlamydia muridarum<\/jats:italic> (<jats:italic>C. muridarum<\/jats:italic>) on development of colitis induced by dextran sodium sulfate (DSS) and the underlying molecular mechanism. The results suggested that <jats:italic>C. muridarum<\/jats:italic> significantly improved colitis symptoms\u2014including weight loss, disease activity index, colon length, and histopathological changes in the colon caused by DSS\u2014and alleviated the reduced expression of interleukin\u201022 and occludin in the colonic tissue due to DSS administration. Furthermore, the absence of IL\u201022 completely prevented <jats:italic>C. muridarum<\/jats:italic> from alleviating colitis and significantly decreased the levels of occludin, an important downstream effector protein of IL\u201022. These findings suggest that <jats:italic>C. muridarum<\/jats:italic> ameliorates ulcerative colitis induced by DSS via the IL\u201022\/occludin signal pathway.<\/jats:p>","DOI":"10.1155\/2020\/8894331","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T01:05:55Z","timestamp":1608253555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>Chlamydia muridarum<\/i> Alleviates Colitis via the IL\u201022\/Occludin Signal Pathway"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-4340","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2890-1439","authenticated-orcid":false,"given":"Huai-cai","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8392-0958","authenticated-orcid":false,"given":"Yan-ru","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6876-2253","authenticated-orcid":false,"given":"Qing-zhi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-017-0813-5"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317571"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0005-8"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.058"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.11.018"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy126"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.09.022"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.04.005"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00630-17"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.03158-14"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.12.002"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01171-15"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00673-15"},{"key":"e_1_2_9_14_2","first-page":"695","article-title":"Pro-versus anti-inflammatory cytokines: myth or reality","volume":"47","author":"Cavaillon J. 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