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To simulate Alzheimer\u2019s disease earlier stages, which manifest in sensory cortices, we used a computational model of the koniocortex that is the first cortical stage processing sensory information. The architecture and physiology of the modeled koniocortex resemble those of its cerebral counterpart being capable of continuous learning. This model allows one to analyze the initial phases of Alzheimer\u2019s disease by \u201caging\u201d the artificial koniocortex through synaptic pruning, by the modification of acetylcholine and GABA-A signaling, and by reducing sensory stimuli, among other processes. The computational model shows that during aging, a GABA-A deficit followed by a reduction in sensory stimuli leads to a dysregulation of neural excitability, which in the biological brain is associated with hypermetabolism, one of the earliest symptoms of Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.1155\/2020\/8895369","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T20:05:06Z","timestamp":1602705906000},"page":"1-26","source":"Crossref","is-referenced-by-count":4,"title":["Alzheimer\u2019s Disease as a Result of Stimulus Reduction in a GABA-A-Deficient Brain: A Neurocomputational Model"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7160-8182","authenticated-orcid":true,"given":"Mariana Antonia","family":"Aguiar-Furucho","sequence":"first","affiliation":[{"name":"Engineering, Neuroscience and Bio-Inspired Systems Study Group (GENeSis), Department of Electrotechnics (DAELT), Universidade Tecnol\u00f3gica Federal do Paran\u00e1 (UTFPR), Paran\u00e1 80230-901, Brazil"},{"name":"Center for Neuroscience and Behavior, Institute of Psychology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8639-4220","authenticated-orcid":true,"given":"Francisco Javier Ropero","family":"Pel\u00e1ez","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Behavior, Institute of Psychology, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Center of Mathematics, Computation and Cognition (CMCC), Universidade Federal do ABC, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902860404"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59426-6.00001-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/2010.001.0001"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1142\/9789812819819_0001"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/5236.001.0001"},{"issue":"5","key":"6","first-page":"509","article-title":"Competitive dynamics in a dual-route connectionist model of print-to-sound transformation","volume":"2","author":"J. 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