{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:25:34Z","timestamp":1789647934663,"version":"4.0.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2020,8,3]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Family with sequence similarity 19 member A5 (FAM19A5), a novel chemokine-like peptide, is a secreted protein mainly expressed in the brain. FAM19A5 was recently found to be involved in a variety of neurological diseases; however, its correlation with vascular dementia (VaD) remains unclear. The aim of the study is to explore the association between serum FAM19A5 and cognitive impairment in subjects with VaD. <jats:italic>Method<\/jats:italic>. 136 VaD subjects and 81 normal controls were recruited in the study. Their demographic and clinical baseline data were collected on admission. All subjects received Mini-Mental State Examination (MMSE) evaluation, which was used to test their cognitive functions. A sandwich enzyme-linked immunosorbent assay (ELISA) was applied to detect the serum levels of FAM19A5. <jats:italic>Results<\/jats:italic>. No significant differences were found between the two groups regarding the demographic and clinical baseline data (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). The serum FAM19A5 levels were significantly higher compared to normal controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The Spearman correlation analysis indicated that serum FAM19A5 levels and MMSE scores have a significant negative correlation in VaD patients (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.414<\/mml:mn><\/mml:math>, &lt;0.001). Further multiple regression analysis indicated that serum FAM19A5 levels were independent risk predictors for cognitive functions in VaD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>\u03b2<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.419<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.031<\/mml:mn><\/mml:math>). <jats:italic>Conclusion<\/jats:italic>. The serum FAM19A5 level of VaD patients is significantly increased, which may serve as a biomarker to predict cognitive function of VaD.<\/jats:p>","DOI":"10.1155\/2020\/8895900","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T23:41:30Z","timestamp":1596498090000},"page":"1-5","source":"Crossref","is-referenced-by-count":19,"title":["Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia"],"prefix":"10.1155","volume":"2020","author":[{"given":"Juan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology, The First People\u2019s Hospital of Lianyungang\/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoulin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First People\u2019s Hospital of Lianyungang\/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First People\u2019s Hospital of Lianyungang\/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First People\u2019s Hospital of Lianyungang\/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First People\u2019s Hospital of Lianyungang\/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, The First People\u2019s Hospital of Lianyungang\/ Department of Neurology, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, Jiangsu Province 222000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, 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