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Electroacupuncture (EA) could improve colonic transit activity in rats with neurogenic bowel dysfunction (NBD) caused by spinal cord injury (SCI). The function of interstitial cells of Cajal (ICCs) and c\u2010Kit expression may play essential roles in this process. <jats:italic>Material and Methods<\/jats:italic>. Thirty\u2010six Sprague Dawley rats were randomized to the sham group, the SCI group, or the SCI\u2009+\u2009EA group (bilateral Zusanli, 30\u2009min\/day, 14 days). Changes in the ultrastructural morphology of ICCs were observed. The c\u2010Kit expression on different levels was analyzed by immunohistochemistry, Western blotting, and RT\u2010qPCR, respectively. <jats:italic>Results<\/jats:italic>. Abnormal morphology of ICCs and downregulation of the c\u2010Kit expression occurred after SCI. While the number of ICCs was increased, the ultrastructural morphology was improved significantly in EA rats. They also showed better improvement in c\u2010Kit expression at both protein and gene levels. <jats:italic>Conclusion<\/jats:italic>. Abnormal ICCs in colon tissues and the downregulated expression of c\u2010Kit could be observed after SCI. EA at Zusanli (ST36) could improve the colon function by repairing the morphology and increasing the number of ICCs and upregulating c\u2010Kit expression.<\/jats:p>","DOI":"10.1155\/2020\/8896123","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T02:20:07Z","timestamp":1606530007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Electroacupuncture at Zusanli (ST36) Repairs Interstitial Cells of Cajal and Upregulates c\u2010Kit Expression in Rats with SCI\u2010Induced Neurogenic Bowel Dysfunction"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-3776","authenticated-orcid":false,"given":"Yujie","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7568-8669","authenticated-orcid":false,"given":"Jie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-6247","authenticated-orcid":false,"given":"Yongni","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8398-2369","authenticated-orcid":false,"given":"Jiabao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7673-7709","authenticated-orcid":false,"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2010.14"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23289"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2015.01.011"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2015.1123845"},{"key":"e_1_2_10_5_2","first-page":"873","article-title":"Assessment of neurogenic bowel dysfunction impact after spinal cord injury using the International Classification of Functioning, Disability and Health","volume":"54","author":"Pires J. 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