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Among comorbidities observed in SARS-CoV-2 positive patients, hypertension (68.3%) and type 2-diabetes (30.1%) are the most frequent conditions. Although symptoms are highly heterogeneous (ranging from absence of symptoms to severe acute respiratory failure), patients with metabolic-associated diseases often experience worse COVID-19 outcomes. This review investigates the association between metabolic disorders and COVID-19 severity, exploring the molecular mechanisms potentially underlying this relationship and those that are responsible for more severe COVID-19 outcomes. In addition, the role of the main biological processes that may connect metabolic alterations to SARS-CoV-2 infection such as hyperglycemia, immune system deregulation, ACE-2 receptor modulation, and inflammatory response is described. The impact of metabolic disorders on the prognosis of COVID-19 has major implications in public health especially for countries affected by a high incidence of metabolic diseases.<\/jats:p>","DOI":"10.1155\/2020\/8896536","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T19:05:15Z","timestamp":1606763115000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-1685","authenticated-orcid":true,"given":"Ersilia","family":"Nigro","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze e Tecnologie Ambientali Biologiche Farmaceutiche, Universit\u00e0 Degli Studi Della Campania \u201cLuigi Vanvitelli\u201d, Via G. Vivaldi 42, Caserta 81100, Italy"},{"name":"CEINGE-Biotecnologie Avanzate Scarl, Via G. 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