{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:05:08Z","timestamp":1790316308205,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Disorders"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p>Background. Systemic and airway inflammation has recently been linked to obstructive sleep apnea-hypopnea syndrome (OSAHS) and is considered to be a probable risk factor for OSAHS-induced cardiovascular damage. High-sensitivity C-reactive protein (hs-CRP), as an inflammatory mediator, may be useful for the prediction of the risk of cardiovascular disease (CVD) and assessment of nocturnal continuous positive airway pressure (nCPAP) therapy effect in OSAHS patients. Methods. A prospective, controlled, cross-sectional study was conducted on 64 consecutive adult subjects with suspected sleep-disordered breathing (SDB). Results. OSAHS was confirmed in 43 patients (24 normotensive and 19 hypertensive patients) and ruled out in 21 normotensive subjects (controls). The median plasma level of hs-CRP did not differ significantly between OSAHS patients and controls. It showed an unmarked rise with the severity of OSAHS (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.20<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and was not correlated with AHI (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.067<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>r<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.28<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). After adjusting for cervical perimeter (CP), waist-to-hip ratio (WHR), and blood sugar level, hs-CRP level of 1\u2009mg\/dL or greater was significantly more often observed in OSAHS patients compared with controls (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.032<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mtext>OR<\/i:mtext>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>5.60<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>) and was also significantly associated with AHI (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.021<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). A significant decrease in the median plasma hs-CRP level was observed in CPAP compliant patients (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.006<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>). Of those, only normotensive patients showed a significant decrease in plasma hs-CRP level. In hypertensive ones, however, the hs-CRP level dropped but not significantly. Using a linear regression model, the change in hs-CRP level (\u0394hs-CRP) following a 6-month-nCPAP therapy was found to positively correlate with the baseline hs-CRP level for both hypertensive (<jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mi>p<\/o:mi>\n                        <o:mo>=<\/o:mo>\n                        <o:mn>0.02<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>r<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.68<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>), and even more normotensive OSAHS patients (<jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>p<\/s:mi>\n                        <s:mo>&lt;<\/s:mo>\n                        <s:mn>0.0001<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>; <jats:inline-formula>\n                     <u:math xmlns:u=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\">\n                        <u:mi>r<\/u:mi>\n                        <u:mo>=<\/u:mo>\n                        <u:mn>0.89<\/u:mn>\n                     <\/u:math>\n                  <\/jats:inline-formula>). Conclusion. nCPAP therapy may have a cardiovascular protective effect in OSAHS patients. hs-CRP level would be useful as a valuable predictor of success in OSAHS treatment monitoring.<\/jats:p>","DOI":"10.1155\/2020\/8913247","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T19:50:07Z","timestamp":1604346607000},"page":"1-10","source":"Crossref","is-referenced-by-count":7,"title":["Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-4548","authenticated-orcid":true,"given":"Sameh","family":"Msaad","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine, H\u00e9di Chaker University Hospital of Sfax, Tunisia"},{"name":"University of Sfax, Faculty of Medicine of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Chaabouni","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, H\u00e9di Chaker University Hospital of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Marrakchi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, H\u00e9di Chaker University Hospital of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariem","family":"Boudaya","sequence":"additional","affiliation":[{"name":"University of Sfax, Faculty of Medicine of Sfax, Tunisia"},{"name":"Department of Biochemistry, H\u00e9di Chaker University Hospital of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Kotti","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine, H\u00e9di Chaker University Hospital of Sfax, Tunisia"},{"name":"University of Sfax, Faculty of Medicine of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Feki","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine, H\u00e9di Chaker University Hospital of Sfax, Tunisia"},{"name":"University of Sfax, Faculty of Medicine of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Jamoussi","sequence":"additional","affiliation":[{"name":"University of Sfax, Faculty of Medicine of Sfax, Tunisia"},{"name":"Department of Biochemistry, H\u00e9di Chaker University Hospital of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy","family":"Kammoun","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Sleep Medicine, H\u00e9di Chaker University Hospital of Sfax, Tunisia"},{"name":"University of Sfax, Faculty of Medicine of Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200709-155MG"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001599"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2015.06.11"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/1358863x18755003"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00086608"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.09.005"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S4078"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.21.2531"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000006850"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106283442601"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.513259"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163017"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052627.99976.18"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/27.8.1507"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364330"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0722-2"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1431"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz145"},{"key":"20","article-title":"BN ProSpec System - 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