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Continuous leakage and hemorrhage of the CNV lesion may eventually result in scarring or later fibrosis, which could result in photoreceptor cell atrophy. The current strategy for treating CNV is the use of antivascular endothelial growth factor (VEGF) agents. Many studies have demonstrated the efficacy of intravitreal anti-VEGF therapy. Other studies have also reported the side effects of single anti-VEGF treatment. And long-term inhibition of a single system may result in collateral damage to other visual elements. Pigment epithelium-derived factor (PEDF) is a 50\u2009kDa protein that was first isolated from the conditioned medium of human RPE cells. PEDF has both antiangiogenesis and neuroprotective functions for photoreceptor cells. It may be a potential ocular antiangiogenic agent. This review outlines the distribution of PEDF in the eye, the mechanism of antiangiogenesis, the protective effect on the retina, and the relationship between PEDF and VEGF.<\/jats:p>","DOI":"10.1155\/2020\/8941057","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T23:31:31Z","timestamp":1583537491000},"page":"1-11","source":"Crossref","is-referenced-by-count":26,"title":["Pigment Epithelium-Derived Factor as a Possible Treatment Agent for Choroidal Neovascularization"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3746-3132","authenticated-orcid":true,"given":"Lei","family":"Xi","sequence":"first","affiliation":[{"name":"Division of Experimental Vitreoretinal Surgery, Centre for Ophthalmology, University of T\u00fcbingen, Schleichstrasse 12\/1, 72076 T\u00fcbingen, 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