{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:39:55Z","timestamp":1747190395361,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lawski Foundation"},{"DOI":"10.13039\/501100011759","name":"Swedish Radiation Safety Authority","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100011759","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,1,14]]},"abstract":"<jats:p>Reactive oxygen species (ROS) at a normal level are important molecules involved in several cellular processes including immune response and cell signalling. Overproduction of ROS may lead to elevated oxidative stress and consequently to age-related diseases. Most of the studies related to oxidative stress in humans have been done on blood samples. However, blood sampling might be painful, requires special qualified personnel, and has to be performed at medical centers. An alternative to blood is saliva. Saliva sampling is noninvasive and can be performed by the donor. Biomarker determination in saliva is becoming an important part of laboratory diagnosis, but method development is needed before it can be used in the clinics. In the present investigation, 16 donors performed extensive physical exercise by cycling and keeping their heart rate at 80% of maximum for 20 minutes. The physical activity was repeated 3 times: before tomato juice intake, after daily intake of 100\u2009ml tomato juice during 3 weeks, and finally 3 weeks after finishing tomato juice intake (washout period). The level of the stress biomarker, salivary 8-oxo-dG, was determined before and after the physical activity. The results indicate that (a) 20\u2009min extensive physical activity increases the level of 8-oxo-dG in saliva significantly (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0078<\/mml:mn><\/mml:math>) and (b) daily intake of 100\u2009ml tomato juice may inhibit (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.052<\/mml:mn><\/mml:math>) overproduction of salivary 8-oxo-dG by 20\u2009min physical activity. We conclude that the 20\u2009min extensive physical activity increases the level of salivary 8-oxo-dG in healthy donors and 100\u2009ml daily intake of tomato juice may inhibit the increase of 8-oxo-dG in saliva.<\/jats:p>","DOI":"10.1155\/2020\/8948723","type":"journal-article","created":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T18:32:37Z","timestamp":1579026757000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Tomato Juice Intake on Salivary 8-Oxo-dG Levels as Oxidative Stress Biomarker after Extensive Physical Exercise"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2570-4875","authenticated-orcid":true,"given":"Ali","family":"Pour Khavari","sequence":"first","affiliation":[{"name":"Centre for Radiation Protection Research, Dept. of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, 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