{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:14:03Z","timestamp":1767168843163,"version":"build-2238731810"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":211,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Low\u2010grade endometrial stromal sarcoma (LG\u2010ESS) is a rare malignant disease and demonstrates various patterns in preoperative imaging. Therefore, accurate diagnosis is important. Given its unique form, we report a case of LG\u2010ESS with a nodule\u2010in\u2010nodule appearance on preoperative imaging. A 41\u2010year\u2010old woman was referred to our department for further examination of a 45\u2009mm diameter uterine corpus mass. Preoperative magnetic resonance imaging (MRI) revealed several small nodules within a larger nodule. T2\u2010weighted images showed moderate\u2010to\u2010high signal intensity with focal bands of low signal intensity in the small nodules. The patient underwent total abdominal hysterectomy and bilateral salpingo\u2010oophorectomy. Histopathological findings of the small nodules showed densely concentrated endometrial stromal cells reminiscent of a proliferative phase endometrium with a concentric arrangement of small spiral arteriole\u2010like vessels. The small nodules exhibited an expansile growth pattern and were surrounded by less densely concentrated endometrial stromal cells intermingled with the normal uterine myometrium. LG\u2010ESS with smooth muscle differentiation and sex cord\u2010like elements was partially observed. In summary, LG\u2010ESS demonstrating a unique nodule\u2010in\u2010nodule appearance on preoperative imaging histopathologically comprised tumor cells of varying densities. Our current case suggests that preoperative diagnostic imaging with MRI may be useful.<\/jats:p>","DOI":"10.1155\/2020\/8973262","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T20:43:27Z","timestamp":1596141807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low\u2010Grade Endometrial Stromal Sarcoma with a Nodule\u2010in\u2010Nodule Appearance in Preoperative Magnetic Resonance 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