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To evaluate the antimalarial effect of aqueous methanolic extract and solvent fractions of <jats:italic>Meriandra dianthera<\/jats:italic> leaves against <jats:italic>Plasmodium berghei<\/jats:italic> in mice model. <jats:italic>Method<\/jats:italic>. <jats:italic>M. dianthera<\/jats:italic> leaves were extracted with 80% methanol and dried. The dried crude extract was then defatted and further fractionated with chloroform, ethyl acetate, and butanol. Acute oral toxicity test was performed as per the Organization for Economic Cooperation and Development guideline 425. Peter\u2019s 4\u2010day suppressive test was used to determine the <jats:italic>in vivo<\/jats:italic> antimalarial activity of the extract and fractions. <jats:italic>Result<\/jats:italic>. The crude leaf extract of <jats:italic>Meriandra dianthera<\/jats:italic> showed parasite inhibition of 42.28% and 45.52% at doses of 400 and 600\u2009mg\/kg, respectively, as compared to the negative control. Moreover, the mice which received chloroform and aqueous fractions at the dose of 400\u2009mg\/kg\/day showed significant (<jats:italic>P<\/jats:italic> &lt; 0.001) chemosuppression compared to the negative control. Both the extract and fractions were able to prevent <jats:italic>P. berghei<\/jats:italic> induced body weight loss and body temperature reduction and also increased the survival time of the mice as compared to the negative control. The aqueous methanolic leaf extract of <jats:italic>M. dianthera<\/jats:italic> showed no gross signs of toxicity or mortality in mice until a single oral dose of 2000\u2009mg\/kg. <jats:italic>Conclusion<\/jats:italic>. The extracts of <jats:italic>M. dianthera<\/jats:italic> leaves showed promising antimalarial activity, with no sign of toxicity and therefore may support its traditional use for the treatment of malaria.<\/jats:p>","DOI":"10.1155\/2020\/8980212","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T23:36:00Z","timestamp":1581550560000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Antimalarial Activity of <i>Meriandra dianthera<\/i> Leaf Extracts in <i>Plasmodium berghei<\/i>\u2010Infected Mice"],"prefix":"10.1155","volume":"2020","author":[{"given":"Kalay","family":"Hagazy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereziher G.","family":"Sibhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6198-1664","authenticated-orcid":false,"given":"Aman","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2301-1453","authenticated-orcid":false,"given":"Gebretsadkan H.","family":"Tekulu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gomathi","family":"Periasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6525-4103","authenticated-orcid":false,"given":"Mebrahtom G.","family":"Hiben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.5455\/jice.20160331064817"},{"key":"e_1_2_11_2_2","volume-title":"The Use of Antimalarial Drugs: Report of an Informal Consultation","author":"Bosman A.","year":"2001"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.79"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.30875\/7e6f8c91-en"},{"key":"e_1_2_11_5_2","first-page":"1440","article-title":"The need of standardized herbal remedies as alternative sources of antimalarial products in Ethiopia: updated review","volume":"3","author":"Petros Z.","year":"2011","journal-title":"Journal of Pharmacology Online"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.2147\/RRTM.S165260"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.5455\/jice.20141231014333"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030197"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.5455\/jice.20150928102856"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-4269-9-65"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13002-015-0015-5"},{"key":"e_1_2_11_12_2","first-page":"613","article-title":"Antimicrobial and cytotoxic abietane diterpenoids from the roots of Meriandera benghalensis (Roxb.) 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