{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T11:35:43Z","timestamp":1781782543030,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":106,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005343","name":"Fundaci\u00f3n IMSS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Neuropeptide Y (NPY) is a sympathetic neurotransmitter with effects on the regulation of inflammatory cells. The role of NPY on autoimmune inflammatory diseases such as rheumatoid arthritis (RA) is not completely understood. Therefore, we evaluate if NPY levels are markers of disease activity in RA and if there is a correlation between NPY levels and tumor necrosis factor\u2010alpha (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ), leptin, and interleukin 6 (IL\u20106) levels.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Cross\u2010sectional design, including 108 women with RA. We assessed disease activity by DAS28\u2010ESR (considering active disease a score of \u22652.6). Serum NPY levels and anti\u2010CCP2 antibody, TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20106, and leptin levels were quantified (ELISA).\n                    <jats:italic>Results<\/jats:italic>\n                    . Sixty\u2010eight RA had an active disease (RA\u2010active), and 40 were in remission (RA\u2010remission). RA\u2010active patients had higher NPY levels vs. RA\u2010remission (22.8 \u00b1 13.6 vs. 17.8 \u00b1 10.3;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.04). NPY levels correlated with increased TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    levels (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.32,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001). Leptin or IL\u20106 did not correlate with NPY levels. In the logistic regression analysis, NPY increased the risk of disease activity (OR: 1.04, 95% CI 1.006\u20101.09, and\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03).\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Higher NPY levels are an independent marker of disease activity in RA. This study encourages the quantification of NPY levels as a surrogate marker for RA\u2010active. Future studies evaluating the role of NPY levels interacting with other proinflammatory cytokines are required.\n                  <\/jats:p>","DOI":"10.1155\/2020\/8982163","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T19:30:46Z","timestamp":1587065446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Serum Neuropeptide Y Levels Are Associated with TNF\u2010\n                    <i>\u03b1<\/i>\n                    Levels and Disease Activity in Rheumatoid Arthritis"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5975-8532","authenticated-orcid":false,"given":"Melissa","family":"Ramirez-Villafa\u00f1a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-9612","authenticated-orcid":false,"given":"Ana M.","family":"Salda\u00f1a-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4491-3381","authenticated-orcid":false,"given":"Javier A.","family":"Aceves-Aceves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-1824","authenticated-orcid":false,"given":"Edsaul E.","family":"Perez-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3471-5835","authenticated-orcid":false,"given":"Nict\u00e9 S.","family":"Fajardo-Robledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3337-7934","authenticated-orcid":false,"given":"Edy D.","family":"Rubio-Arellano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3562-7033","authenticated-orcid":false,"given":"Cesar A.","family":"Nava-Valdivia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4066-3135","authenticated-orcid":false,"given":"Maria O.","family":"Carrillo-Escalante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-0831","authenticated-orcid":false,"given":"Sylvia E.","family":"Totsuka-Sutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-2489","authenticated-orcid":false,"given":"David","family":"Cardona-M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-3481","authenticated-orcid":false,"given":"Betsabe","family":"Contreras-Haro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3391-6907","authenticated-orcid":false,"given":"Mario","family":"Salazar-Paramo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-667X","authenticated-orcid":false,"given":"Ernesto G.","family":"Cardona-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8515-0777","authenticated-orcid":false,"given":"M.","family":"Huerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0001-3787","authenticated-orcid":false,"given":"Jorge I.","family":"Gamez-Nava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-6298","authenticated-orcid":false,"given":"Norma A.","family":"Rodriguez-Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-6344","authenticated-orcid":false,"given":"Laura","family":"Gonzalez-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,16]]},"reference":[{"key":"e_1_2_9_1_2","article-title":"Rheumatoid arthritis","volume":"8","author":"Smolen J. 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