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The patients were grouped according to type of schizophrenia and type of disease course. We found that IgGs isolated and purified from sera of schizophrenia patients\u2019 blood hydrolyses human MBP, and the level of this hydrolysis significantly exceeds that of healthy individuals. Detection of protease activity corresponding only to intact IgGs in polyacrylamide gel fragments, together with data of gel filtration of antibodies under conditions of \u201cacid shock\u201d (concordance of optical density profile of IgG with profile of MBP\u2010hydrolyzing activity) and with the absence of any other proteins and bands in gradient SDS\u2010PAGE and in PVDF membrane provides direct evidence that the IgGs from the schizophrenia patients have MBP\u2010hydrolyzing activity. The antibodies\u2010specific proteolytic activity of patients with acute schizophrenia (1.026 [0.205; 3.372] mg MBP\/mg IgG\/h) significantly exceeds the activity of IgG in patients in remission (0.656 [0.279; 0.873] mg MBP\/mg IgG\/h) and in healthy individuals (0.000 [0.00; 0.367] mg MBP\/mg IgG\/h). When comparing the specific activity in patients with different types of disease course, we have found that patients with a continuous course of paranoid schizophrenia (1.810 [0.746; 4.101\u2009mg MBP\/mg IgG\/h]) had maximal activity values. It can be assumed that the increase in the activity of MBP\u2010hydrolyzing antibodies is due to the activation of humoral immunity in acute schizophrenia.<\/jats:p>","DOI":"10.1155\/2020\/8986521","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T20:03:42Z","timestamp":1597176222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Igg\u2010Dependent Hydrolysis of Myelin Basic Protein of Patients with Different Courses of Schizophrenia"],"prefix":"10.1155","volume":"2020","author":[{"given":"Daria A.","family":"Parshukova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0083-9124","authenticated-orcid":false,"given":"Liudmila P.","family":"Smirnova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena G.","family":"Kornetova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiy V.","family":"Semke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina N.","family":"Buneva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7078-323X","authenticated-orcid":false,"given":"Svetlana A.","family":"Ivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2006.07.006"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.163.3.521"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796016000561"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00131"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001653"},{"key":"e_1_2_8_6_2","first-page":"81","article-title":"Inflammatory and autoimmune reactions in different forms of nervous system functioning disorders","volume":"45","author":"Otman I. 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