{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:59:52Z","timestamp":1758970792495,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T00:00:00Z","timestamp":1579651200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Resveratrol (3,5,4\u2032\u2010trihydroxystilbene) is a chemical compound belonging to the group of polyphenols and flavonoids. The aim of the present study was to determine the influence of resveratrol application along with certain modulating factors, such as 8Br\u2010cGMP\u2010activator of cGMP\u2010dependent protein kinases, HA\u20101077\u2010Rho\u2010kinase inhibitor, and Bay K8644\u2010calcium channel agonist, on VMSCs constriction triggered by phenylephrine. Resveratrol at a dose of 10\u2009mg\/kg\/24\u2009h administered for 4 weeks reduced the reactivity of the arteries to the pressure action of catecholamines. Tests performed after four weeks of resveratrol administration showed that 8Br\u2010cGMP at the concentrations of 0.01\u2009mM\/l and 0.1\u2009mM\/l intensifies this effect. Simultaneous resveratrol and Bay K8644 administration led to a significant decrease in contractility compared to the vessels collected from animals (Res\u2212). This effect was dependent on the concentration of Bay K8644. Resveratrol seems to be counteractive against Bay K8644 by blocking L\u2010type calcium channels. As the concentration of HA\u20101077 increased, there was a marked hyporeactivity of the vessels to the pressure effects of phenylephrine. The results indicate synergy between resveratrol and Rho\u2010kinase inhibition.<\/jats:p>","DOI":"10.1155\/2020\/9012071","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T23:32:33Z","timestamp":1579735953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Resveratrol\u2019s Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho\u2010Kinase Inhibition"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-0171","authenticated-orcid":false,"given":"Micha\u0142","family":"Wici\u0144ski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Malinowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-8840","authenticated-orcid":false,"given":"Pawe\u0142","family":"Rajewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Szychta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2834-3414","authenticated-orcid":false,"given":"Eryk","family":"W\u00f3dkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Walczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"G\u00f3rski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Pawlak-Osi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"S\u0142upski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0112973"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.09.015"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2895"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/138161212798919075"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs135"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.010652"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1992.tb14537.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2008.09.002"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.cp0070027"},{"key":"e_1_2_8_10_2","first-page":"299","article-title":"Cumulative dose-response curves. Technique for the making of dose-response curves in isolatedorgans and the evaluation of drug parameters","volume":"143","author":"van Rossum J. M.","year":"1963","journal-title":"Arch Int Pharmacodyn et Therapie"},{"volume-title":"Pharmacologic Analysis of Drug\u2014Receptor Interaction","year":"1997","author":"Kenakin T.","key":"e_1_2_8_11_2"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4180"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.066423"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.5056\/jnm14093"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.29.1_supplement.1049.3"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9202954"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000312665"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.90"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.08.003"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1223"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2018.05.002"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/372231a0"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-2-00177.x"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/hjh.0b013e328362adb3"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-9542"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020523001107"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.100040"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/9012071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/9012071.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/9012071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T09:33:07Z","timestamp":1735637587000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/9012071"}},"subtitle":[],"editor":[{"given":"Christina","family":"Pabelick","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/9012071"],"URL":"https:\/\/doi.org\/10.1155\/2020\/9012071","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"type":"print","value":"2314-6133"},{"type":"electronic","value":"2314-6141"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9012071"}}